Extensive Natural Epigenetic Variation At A De Novo Originated Gene.

dc.creatorSilveira, Amanda Bortolini
dc.creatorTrontin, Charlotte
dc.creatorCortijo, Sandra
dc.creatorBarau, Joan
dc.creatorDel Bem, Luiz Eduardo Vieira
dc.creatorLoudet, Olivier
dc.creatorColot, Vincent
dc.creatorVincentz, Michel
dc.date2013-Apr
dc.date2015-11-27T13:31:38Z
dc.date2015-11-27T13:31:38Z
dc.date.accessioned2018-03-29T01:17:37Z
dc.date.available2018-03-29T01:17:37Z
dc.identifierPlos Genetics. v. 9, n. 4, p. e1003437, 2013-Apr.
dc.identifier1553-7404
dc.identifier10.1371/journal.pgen.1003437
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23593031
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200591
dc.identifier23593031
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300824
dc.descriptionEpigenetic variation, such as heritable changes of DNA methylation, can affect gene expression and thus phenotypes, but examples of natural epimutations are few and little is known about their stability and frequency in nature. Here, we report that the gene Qua-Quine Starch (QQS) of Arabidopsis thaliana, which is involved in starch metabolism and that originated de novo recently, is subject to frequent epigenetic variation in nature. Specifically, we show that expression of this gene varies considerably among natural accessions as well as within populations directly sampled from the wild, and we demonstrate that this variation correlates negatively with the DNA methylation level of repeated sequences located within the 5'end of the gene. Furthermore, we provide extensive evidence that DNA methylation and expression variants can be inherited for several generations and are not linked to DNA sequence changes. Taken together, these observations provide a first indication that de novo originated genes might be particularly prone to epigenetic variation in their initial stages of formation.
dc.description9
dc.descriptione1003437
dc.languageeng
dc.relationPlos Genetics
dc.relationPLoS Genet.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subject5' Untranslated Regions
dc.subjectArabidopsis
dc.subjectArabidopsis Proteins
dc.subjectBase Sequence
dc.subjectDna Methylation
dc.subjectEpigenesis, Genetic
dc.subjectGene Expression Regulation, Plant
dc.subjectGenetic Variation
dc.subjectPhenotype
dc.subjectStarch
dc.titleExtensive Natural Epigenetic Variation At A De Novo Originated Gene.
dc.typeArtículos de revistas


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