Antimicrobial And Antiproliferative Activities Of Stingless Bee Melipona Scutellaris Geopropolis.

dc.creatorda Cunha, Marcos Guilherme
dc.creatorFranchin, Marcelo
dc.creatorde Carvalho Galvão, Lívia Câmara
dc.creatorde Ruiz, Ana Lúcia Tasca Góis
dc.creatorde Carvalho, João Ernesto
dc.creatorIkegaki, Masarahu
dc.creatorde Alencar, Severino Matias
dc.creatorKoo, Hyun
dc.creatorRosalen, Pedro Luiz
dc.date2013
dc.date2015-11-27T13:31:17Z
dc.date2015-11-27T13:31:17Z
dc.date.accessioned2018-03-29T01:17:07Z
dc.date.available2018-03-29T01:17:07Z
dc.identifierBmc Complementary And Alternative Medicine. v. 13, p. 23, 2013.
dc.identifier1472-6882
dc.identifier10.1186/1472-6882-13-23
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23356696
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200460
dc.identifier23356696
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300693
dc.descriptionGeopropolis is a type of propolis containing resin, wax, and soil, collected by threatened stingless bee species native to tropical countries and used in folk medicine. However, studies concerning the biological activity and chemical composition of geopropolis are scarce. In this study, we evaluated the antimicrobial and antiproliferative activity of the ethanolic extract of geopropolis (EEGP) collected by Melipona scutellaris and its bioactive fraction against important clinical microorganisms as well as their in vitro cytotoxicity and chemical profile. The antimicrobial activity of EEGP and fractions was examined by determining their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against six bacteria strains as well as their ability to inhibit Streptococcus mutans biofilm adherence. Total growth inhibition (TGI) was chosen to assay the antiproliferative activity of EEGP and its bioactive fraction against normal and cancer cell lines. The chemical composition of M. scutellaris geopropolis was identified by reversed-phase high-performance liquid chromatography and gas chromatography-mass spectrometry. EEGP significantly inhibited the growth of Staphylococcus aureus strains and S. mutans at low concentrations, and its hexane fraction (HF) presented the highest antibacterial activity. Also, both EEGP and HF inhibited S. mutans biofilm adherence (p < 0.05) and showed selectivity against human cancer cell lines, although only HF demonstrated selectivity at low concentrations. The chemical analyses performed suggest the absence of flavonoids and the presence of benzophenones as geopropolis major compounds. The empirical use of this unique type of geopropolis by folk medicine practitioners was confirmed in the present study, since it showed antimicrobial and antiproliferative potential against the cancer cell lines studied. It is possible that the major compounds found in this type of geopropolis are responsible for its properties.
dc.description13
dc.description23
dc.languageeng
dc.relationBmc Complementary And Alternative Medicine
dc.relationBMC Complement Altern Med
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-bacterial Agents
dc.subjectAntineoplastic Agents
dc.subjectApitherapy
dc.subjectBees
dc.subjectBenzophenones
dc.subjectBiofilms
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectPropolis
dc.subjectStaphylococcus Aureus
dc.subjectStreptococcus Mutans
dc.titleAntimicrobial And Antiproliferative Activities Of Stingless Bee Melipona Scutellaris Geopropolis.
dc.typeArtículos de revistas


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