Serological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole.

dc.creatorAguiar, Camila
dc.creatorBatista, Angelica M
dc.creatorPavan, Tycha B S
dc.creatorAlmeida, Eros A
dc.creatorGuariento, Maria E
dc.creatorWanderley, Jamiro S
dc.creatorCosta, Sandra C B
dc.date2012-Mar
dc.date2015-11-27T13:29:17Z
dc.date2015-11-27T13:29:17Z
dc.date.accessioned2018-03-29T01:16:55Z
dc.date.available2018-03-29T01:16:55Z
dc.identifierTropical Medicine & International Health : Tm & Ih. v. 17, n. 3, p. 368-73, 2012-Mar.
dc.identifier1365-3156
dc.identifier10.1111/j.1365-3156.2011.02936.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22212647
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200410
dc.identifier22212647
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300643
dc.descriptionTo evaluate the serological and parasitological status of patients with chronic Chagas disease (CD) after chemotherapy with benzonidazole. Retrospective study of patients treated with benzonidazole (5 mg/kg/day for 60 days) between 1980 and 2010. Twenty-nine patients who had CD confirmed by two reagent immunological tests and/or one positive xenodiagnosis before treatment were included. Conventional serology (ELISA and IIF) and parasitological tests (haemoculture and N-PCR) were performed. At the time of treatment, the mean age of patients was 36 ± 7.24 years (20-39 years) and the time post-treatment varied from 1 to 29 years. After chemotherapy, all individuals had reagent ELISA and 93.1% had positive results for the IIF test. T. cruzi DNA was detected by N-PCR in 48.3%. Negative results were observed in 41.4% and inconclusive ones in 10.3%. Haemoculture was negative for all individuals. Our results suggest that N-PCR may be useful in the early identification of therapeutic failure of CD. Although it is difficult to determine parasitological cure in negative N-PCR cases, we can infer that this condition represents a declination of parasitaemia as a favourable consequence of aetiological treatment.
dc.description17
dc.description368-73
dc.languageeng
dc.relationTropical Medicine & International Health : Tm & Ih
dc.relationTrop. Med. Int. Health
dc.rightsfechado
dc.rights© 2011 Blackwell Publishing Ltd.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAntibodies, Protozoan
dc.subjectChagas Disease
dc.subjectChronic Disease
dc.subjectDna, Protozoan
dc.subjectEnzyme-linked Immunosorbent Assay
dc.subjectFemale
dc.subjectFluorescent Antibody Technique, Indirect
dc.subjectHumans
dc.subjectMale
dc.subjectNitroimidazoles
dc.subjectParasitemia
dc.subjectPolymerase Chain Reaction
dc.subjectRetrospective Studies
dc.subjectTreatment Failure
dc.subjectTrypanocidal Agents
dc.subjectTrypanosoma Cruzi
dc.subjectYoung Adult
dc.titleSerological Profiles And Evaluation Of Parasitaemia By Pcr And Blood Culture In Individuals Chronically Infected By Trypanosoma Cruzi Treated With Benzonidazole.
dc.typeArtículos de revistas


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