Enhanced Insulin Secretion And Glucose Tolerance In Rats Exhibiting Low Plasma Free Fatty Acid Levels And Hypertriglyceridaemia Due To Congenital Albumin Deficiency.

dc.creatorFigueira, Tiago R
dc.creatorRibeiro, Rosane A
dc.creatorIgnacio-Souza, Letícia M
dc.creatorVercesi, Anibal E
dc.creatorCarneiro, Everardo M
dc.creatorOliveira, Helena C F
dc.date2012-Apr
dc.date2015-11-27T13:29:17Z
dc.date2015-11-27T13:29:17Z
dc.date.accessioned2018-03-29T01:16:54Z
dc.date.available2018-03-29T01:16:54Z
dc.identifierExperimental Physiology. v. 97, n. 4, p. 525-33, 2012-Apr.
dc.identifier1469-445X
dc.identifier10.1113/expphysiol.2011.062307
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22198013
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200409
dc.identifier22198013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300642
dc.descriptionCongenitally analbuminaemic individuals and rats (NARs) exhibit several metabolic abnormalities, including hypertriglyceridaemia and plasma free fatty acid deficiency. Our aim was to study glucose homeostasis and insulin secretion in NARs. Plasma concentrations of lipids, glucose and insulin and secretion of insulin from the pancreatic islets were measured in female NARs and control animals (Sprague-Dawley rats; SDRs). Glucose homeostasis tests were also performed. Plasma glucose levels were similar between NARs and SDRs, irrespective of feeding status. However, fed insulinaemia was ∼37% higher (P 0.05) in NARs than in SDRs. The NARs displayed a markedly increased glucose tolerance, i.e. the integrated glycaemic response was one-third that of the control animals. Enhanced glucose tolerance was associated with threefold higher insulinaemia at peak glycaemia after a glucose load than in the control animals. Similar peripheral insulin sensitivity was observed between groups. Isolated pancreatic islets from NARs secreted significantly more insulin than islets from SDRs in response to a wide range of glucose concentrations (2.8-33.3 mm). Despite having similar liver glycogen contents in the fully fed state, NARs had ∼40% (P 0.05) lower glycogen contents than SDRs after 6 h fasting. The injection of a gluconeogenic substrate, pyruvate, elicited a faster rise in glycaemia in NARs compared with SDRs. Overall, NARs displayed enhanced glucose tolerance, insulin secretion and gluconeogenic flux. The higher glucose tolerance in NARs compared with SDRs is attributed to enhanced islet responsiveness to secretagogues, while peripheral insulin sensitivity seems not to be involved in this alteration. We propose that the enhanced glucose metabolism is a chronic compensatory adaptation to decreased free fatty acid availability in NARs.
dc.description97
dc.description525-33
dc.languageeng
dc.relationExperimental Physiology
dc.relationExp. Physiol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectDeficiency Diseases
dc.subjectFatty Acids, Nonesterified
dc.subjectFemale
dc.subjectGlucose Tolerance Test
dc.subjectHypertriglyceridemia
dc.subjectInsulin
dc.subjectIslets Of Langerhans
dc.subjectRats
dc.subjectRats, Sprague-dawley
dc.subjectSerum Albumin
dc.titleEnhanced Insulin Secretion And Glucose Tolerance In Rats Exhibiting Low Plasma Free Fatty Acid Levels And Hypertriglyceridaemia Due To Congenital Albumin Deficiency.
dc.typeArtículos de revistas


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