Weight Loss And Resting Energy Expenditure In Patients With Chronic Hepatitis C Before And During Standard Treatment.

dc.creatorFioravante, Milena
dc.creatorAlegre, Sarah Monte
dc.creatorMarin, Daniela Miguel
dc.creatorLorena, Sonia Leticia Silva
dc.creatorPereira, Tiago Sevá
dc.creatorSoares, Elza Cotrim
dc.date2012-Jun
dc.date2015-11-27T13:29:17Z
dc.date2015-11-27T13:29:17Z
dc.date.accessioned2018-03-29T01:16:54Z
dc.date.available2018-03-29T01:16:54Z
dc.identifierNutrition (burbank, Los Angeles County, Calif.). v. 28, n. 6, p. 630-4, 2012-Jun.
dc.identifier1873-1244
dc.identifier10.1016/j.nut.2011.08.010
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22196981
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200407
dc.identifier22196981
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300640
dc.descriptionInfection with hepatitis C virus (HCV) is a serious public health problem worldwide. In clinical studies, weight loss has been reported in 11% to 29% of patients treated with pegylated interferon-α-2a/2b. Few reports have tried to explain such a weight loss. The aim of this study was to evaluate nutritional status, body composition, and resting energy expenditure (REE) in patients with chronic hepatitis C before and during treatment with pegylated interferon and ribavirin. This was a prospective study with the evaluation of patients with hepatitis C virus before and after 12 wk of treatment with pegylated interferon and ribavirin. The evaluation consisted of anthropometry (weight, height, body mass index, and waist circumference), and body composition was determined by bioelectrical impedance analysis. The REE of each individual was obtained by indirect calorimetry. To compare the two phases of treatment, the Wilcoxon test was used. The significance level was 5%. Subjects had significant weight loss during treatment with a consequent decrease in body mass index. This weight decrease was accompanied by a significant decrease in body fat and no decrease in fat-free mass. There was a significant decrease in energy intake as assessed by 24-h recall. However, there was no change in REE and in REE corrected for fat-free mass. Our study of patients with hepatitis C treatment showed that these patients had significant weight loss and this was not associated with changes in energy expenditure. However, we observed a significant decrease in energy intake, pointing to a possible need for intervention measures to decrease the damage.
dc.description28
dc.description630-4
dc.languageeng
dc.relationNutrition (burbank, Los Angeles County, Calif.)
dc.relationNutrition
dc.rightsfechado
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAdipose Tissue
dc.subjectAdult
dc.subjectAntiviral Agents
dc.subjectBasal Metabolism
dc.subjectBody Fluid Compartments
dc.subjectBody Mass Index
dc.subjectDiet Records
dc.subjectEnergy Intake
dc.subjectFemale
dc.subjectHepatitis C, Chronic
dc.subjectHumans
dc.subjectInterferon-alpha
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolyethylene Glycols
dc.subjectProspective Studies
dc.subjectRecombinant Proteins
dc.subjectRibavirin
dc.subjectStandard Of Care
dc.subjectStatistics, Nonparametric
dc.subjectWeight Loss
dc.titleWeight Loss And Resting Energy Expenditure In Patients With Chronic Hepatitis C Before And During Standard Treatment.
dc.typeArtículos de revistas


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