Artículos de revistas
Populene D Analogues: Design, Concise Synthesis And Antiproliferative Activity.
Registro en:
Molecules (basel, Switzerland). v. 17, n. 8, p. 9621-30, 2012.
1420-3049
10.3390/molecules17089621
23442985
Autor
Reddy, Kachi R Kishore Kumar
Longato, Giovanna B
de Carvalho, João E
Ruiz, Ana L T G
Silva, Luiz F
Institución
Resumen
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered. 17 9621-30