Vascular Stiffness And Endothelial Dysfunction: Correlations At Different Levels Of Blood Pressure.

dc.creatorFigueiredo, Valéria Nasser
dc.creatorYugar-Toledo, Juan Carlos
dc.creatorMartins, Luiz Cláudio
dc.creatorMartins, Leandro Boer
dc.creatorde Faria, Ana Paula Cabral
dc.creatorde Haro Moraes, Carolina
dc.creatorSierra, Cristina
dc.creatorCoca, Antonio
dc.creatorMoreno, Heitor
dc.date2012-Feb
dc.date2015-11-27T13:29:04Z
dc.date2015-11-27T13:29:04Z
dc.date.accessioned2018-03-29T01:16:27Z
dc.date.available2018-03-29T01:16:27Z
dc.identifierBlood Pressure. v. 21, n. 1, p. 31-8, 2012-Feb.
dc.identifier1651-1999
dc.identifier10.3109/08037051.2011.617045
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22029740
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200289
dc.identifier22029740
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300522
dc.descriptionResistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance to antihypertensive treatment and cardiovascular complications. Biophysical forces within the arterial wall provide functional regulation of arterial stiffness. Carotid-femoral pulse wave velocity (PWV) and flow-mediated brachial artery dilation (FMD) can be used to evaluate vascular stiffness and endothelial function. Although both techniques have been used in several studies in hypertensive patients, it is unknown whether endothelial dysfunction is also associated with vascular stiffness in RHTN patients. One hundred and ninety-three consecutive subjects were divided in three groups: 44 RHTN, 35 well-controlled hypertensive patients (HTN) and 25 normal healthy volunteers (NT). FMD was measured by high-resolution ultrasound and PWV was calculated from measurements of the pulse transit time and the distance traveled by the pulse between carotid and femoral arteries. No significant differences were observed in respect to body mass index, age or other biochemical variables among the three groups. FMD (NO-dependent) values were statistically different when comparing RHTN and well controlled HTN patients (respectively, 8.3 ± 4.7% and 10.1 ± 5.9%) and 12.3 ± 6.3% in normal subjects (p < 0.05). One-way analysis of variance (ANOVA) showed a significant difference in BP-adjusted PWV between RHTN and HTN (13.9 ± 1.0 and 11.5 ± 1.1 m/s, respectively; p < 0.05). FMD (NO-dependent) and PWV-adjusted values were strongly correlated in well-controlled HTN and NT subjects (r = - 0.74 and - 0.83, respectively). Although statistically significant, this correlation was lower in RHTN patients (r = - 0.43). We found a close relationship among high BP levels, endothelial dysfunction and vascular rigidity in hypertensive patients, demonstrated by a significantly higher increase in carotid-femoral PWV and a decrease in brachial artery FMD in RHTN when compared with well-controlled hypertensive patients. Although this study was not designed to test the prognostic, the vascular damage differences observed between patients with controlled vs uncontrolled hypertension suggest that the latter group may have a worse cardiovascular prognosis, requiring prospective assessment tests.
dc.description21
dc.description31-8
dc.languageeng
dc.relationBlood Pressure
dc.relationBlood Press.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis Of Variance
dc.subjectAntihypertensive Agents
dc.subjectBlood Flow Velocity
dc.subjectBlood Pressure
dc.subjectBlood Pressure Determination
dc.subjectBrachial Artery
dc.subjectCarotid Arteries
dc.subjectCase-control Studies
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectFemoral Artery
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNitric Oxide
dc.subjectProspective Studies
dc.subjectPulsatile Flow
dc.subjectVascular Stiffness
dc.titleVascular Stiffness And Endothelial Dysfunction: Correlations At Different Levels Of Blood Pressure.
dc.typeArtículos de revistas


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