Homogeneity Study Of Ointment Dosage Forms By Infrared Imaging Spectroscopy.

dc.creatorCarneiro, Renato Lajarim
dc.creatorPoppi, Ronei Jesus
dc.date2012-Jan
dc.date2015-11-27T13:29:01Z
dc.date2015-11-27T13:29:01Z
dc.date.accessioned2018-03-29T01:16:22Z
dc.date.available2018-03-29T01:16:22Z
dc.identifierJournal Of Pharmaceutical And Biomedical Analysis. v. 58, p. 42-8, 2012-Jan.
dc.identifier1873-264X
dc.identifier10.1016/j.jpba.2011.09.031
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22018891
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200267
dc.identifier22018891
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300500
dc.descriptionOintment dosage forms are semi-solid preparations intended for local or transdermal delivery of active substances usually for application to the skin and it is important that they present a homogeneous appearance. In this work, a study of the homogeneity of a tacrolimus ointment dosage form was performed using infrared imaging spectroscopy coupled with principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS) to interpret the imaging data. Optical visible microscopy images indicated possible phase separation in the ointment and, based on the results presented by distribution concentration maps from infrared imaging, it was possible to conclude that, in fact, there was phase separation incorporated in the ointment. Thus, infrared imaging spectroscopy associated to PCA and MCR-ALS is demonstrated to be a powerful tool for the development process of ointment dosage forms.
dc.description58
dc.description42-8
dc.languageeng
dc.relationJournal Of Pharmaceutical And Biomedical Analysis
dc.relationJ Pharm Biomed Anal
dc.rightsfechado
dc.rightsCopyright © 2011 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectDosage Forms
dc.subjectLeast-squares Analysis
dc.subjectMicroscopy
dc.subjectMultivariate Analysis
dc.subjectOintments
dc.subjectPrincipal Component Analysis
dc.subjectSpectroscopy, Near-infrared
dc.subjectTacrolimus
dc.titleHomogeneity Study Of Ointment Dosage Forms By Infrared Imaging Spectroscopy.
dc.typeArtículos de revistas


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