Suramin Affects Metalloproteinase-9 Activity And Increases β-dystroglycan Levels In The Diaphragm Of The Dystrophin-deficient Mdx Mouse.

dc.creatorTaniguti, Ana Paula Tiemi
dc.creatorMatsumura, Cíntia Yuri
dc.creatorRodrigues-Simioni, Léa
dc.creatorSanto Neto, Humberto
dc.creatorMarques, Maria Julia
dc.date2012-Nov
dc.date2015-11-27T13:28:57Z
dc.date2015-11-27T13:28:57Z
dc.date.accessioned2018-03-29T01:16:14Z
dc.date.available2018-03-29T01:16:14Z
dc.identifierMuscle & Nerve. v. 46, n. 5, p. 810-3, 2012-Nov.
dc.identifier1097-4598
dc.identifier10.1002/mus.23468
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23055317
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200232
dc.identifier23055317
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300465
dc.descriptionIn Duchenne muscular dystrophy and in the mdx mouse, muscle fiber degeneration and subsequent fibrosis lead to cardiorespiratory failure. Previously, we demonstrated that the anti-fibrotic agent suramin was effective in decreasing fibrosis in mdx muscles. In this study, we were interested to see whether suramin could affect metalloproteinases (MMP) and improve the functional activity of the mdx diaphragm muscle. Zymography was performed to evaluate MMP-2 and MMP-9 activity. Western blotting was used to analyze the levels of beta-dystroglycan. Muscle function was assessed in hemidiaphragm in vitro preparations. We found that suramin affects metalloproteinase-9 activity and increases beta-dystroglycan. Furthermore, suramin also protects against diaphragm muscle fatigue over time. These results show the potential benefits of suramin in maintaining the structure of the dystrophin-glycoprotein complex.
dc.description46
dc.description810-3
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightsCopyright © 2012 Wiley Periodicals, Inc.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDiaphragm
dc.subjectDystroglycans
dc.subjectDystrophin
dc.subjectEnzyme Activation
dc.subjectFemale
dc.subjectFibrosis
dc.subjectMale
dc.subjectMatrix Metalloproteinase 9
dc.subjectMatrix Metalloproteinase Inhibitors
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectMuscle Fatigue
dc.subjectMuscular Dystrophy, Duchenne
dc.subjectSuramin
dc.subjectUp-regulation
dc.titleSuramin Affects Metalloproteinase-9 Activity And Increases β-dystroglycan Levels In The Diaphragm Of The Dystrophin-deficient Mdx Mouse.
dc.typeArtículos de revistas


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