Analysis Of The Deep Digital Flexor Tendon In Rats Submitted To Stretching After Immobilization.

dc.creatorde Aro, Andrea Aparecida
dc.creatorVidal, Benedicto de Campos
dc.creatorBiancalana, Adriano
dc.creatorTolentino, Felipe Thadeu
dc.creatorGomes, Laurecir
dc.creatorMattiello, Stela Márcia
dc.creatorPimentel, Edson Rosa
dc.date2012
dc.date2015-11-27T13:28:56Z
dc.date2015-11-27T13:28:56Z
dc.date.accessioned2018-03-29T01:16:12Z
dc.date.available2018-03-29T01:16:12Z
dc.identifierConnective Tissue Research. v. 53, n. 1, p. 29-38, 2012.
dc.identifier1607-8438
dc.identifier10.3109/03008207.2011.608868
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21967646
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200223
dc.identifier21967646
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300456
dc.descriptionFew studies have analyzed the effect of stretching after immobilization on the structural and biochemical properties of tendons. Here, the effect of stretching and immobilization on the proximal (p), intermediate (i), and distal (d) regions of the deep digital flexor tendon in rats was analyzed. The d region was subjected to compression and tension forces, the i region was subjected to compressive forces and the p region received tension forces. Rats were separated into five groups: GI--control for GII; GII--immobilized rats; GIII--control for GIV and GV groups; GIV--immobilized and stretched rats; and GV--immobilized rats which were allowed free cage activity. GII showed a higher molecular organization in the d and p regions as detected by measuring optical retardation, a lower concentration of hydroxyproline in the i region and a significant decrease in noncollagenous proteins found in the three regions of the tendon. Regarding the glycosaminoglycans, diminishing dermatan sulfate and the absence of chondroitin sulfate in the i region were observed in GII when compared to GI. However, in the same region of GIV, higher concentrations of chondroitin and dermatan sulfate were observed along with a strong metachromasy. An increase in hydroxyproline content in the i region and a higher molecular organization in the d and p regions were observed in GIV. Apparently, the active isoforms of metalloproteinase-2 also increased after stretching in all regions. These results suggest that stretching after immobilization contributed to the increase in molecular organization and to the synthesis of extracellular matrix components.
dc.description53
dc.description29-38
dc.languageeng
dc.relationConnective Tissue Research
dc.relationConnect. Tissue Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectElectrophoresis, Agar Gel
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectFibrillar Collagens
dc.subjectHydroxyproline
dc.subjectImmobilization
dc.subjectMale
dc.subjectMuscle Stretching Exercises
dc.subjectOrthotic Devices
dc.subjectProteolysis
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTendons
dc.subjectTissue Extracts
dc.titleAnalysis Of The Deep Digital Flexor Tendon In Rats Submitted To Stretching After Immobilization.
dc.typeArtículos de revistas


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