Doxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice.

dc.creatorPereira, Juliano Alves
dc.creatorTaniguti, Ana Paula Tiemi
dc.creatorMatsumura, Cíntia
dc.creatorMarques, Maria Julia
dc.creatorNeto, Humberto Santo
dc.date2012-Sep
dc.date2015-11-27T13:28:49Z
dc.date2015-11-27T13:28:49Z
dc.date.accessioned2018-03-29T01:15:57Z
dc.date.available2018-03-29T01:15:57Z
dc.identifierMuscle & Nerve. v. 46, n. 3, p. 400-6, 2012-Sep.
dc.identifier1097-4598
dc.identifier10.1002/mus.23331
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22907231
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200160
dc.identifier22907231
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300393
dc.descriptionWe examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. This study provides evidence that doxycycline may be a potential therapeutic agent for DMD.
dc.description46
dc.description400-6
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightsCopyright © 2012 Wiley Periodicals, Inc.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-bacterial Agents
dc.subjectDoxycycline
dc.subjectFibrosis
dc.subjectHeart
dc.subjectMice
dc.subjectMice, Inbred Mdx
dc.subjectMuscle Strength
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophy, Animal
dc.subjectMyocardium
dc.subjectPhenotype
dc.titleDoxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice.
dc.typeArtículos de revistas


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