Schistosoma Mansoni: In Vitro Schistosomicidal Activity Of Essential Oil Of Baccharis Trimera (less) Dc.

dc.creatorde Oliveira, Rosimeire Nunes
dc.creatorRehder, Vera Lúcia Garcia
dc.creatorSantos Oliveira, Adriana S
dc.creatorJúnior, Ílio Montanari
dc.creatorde Carvalho, João Ernesto
dc.creatorde Ruiz, Ana Lúcia Tasca Gois
dc.creatorJeraldo, Veronica de Lourdes Sierpe
dc.creatorLinhares, Arício Xavier
dc.creatorAllegretti, Silmara Marques
dc.date2012-Oct
dc.date2015-11-27T13:28:42Z
dc.date2015-11-27T13:28:42Z
dc.date.accessioned2018-03-29T01:15:42Z
dc.date.available2018-03-29T01:15:42Z
dc.identifierExperimental Parasitology. v. 132, n. 2, p. 135-43, 2012-Oct.
dc.identifier1090-2449
dc.identifier10.1016/j.exppara.2012.06.005
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22771865
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200097
dc.identifier22771865
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300330
dc.descriptionSchistosomiasis is a chronic parasitic disease caused by the trematode species Schistosoma mansoni. Chemotherapy is the only immediate recourse to minimize the prevalence and incidence of this disease worldwide. At present, praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis. However, dependence on a single drug is concern because some strains can become resistant. In this context, medicinal plants become potential candidates as sources of new drug prototypes. This study provides findings on the schistosomicidal activity of the essential oil of Baccharis trimera in in vitro assays. During the assays parameters such as motility of adult worms, oviposition, morphological changes on the tegument and especially the mortality rate of adult worms of the BH strain were evaluated. The assays, which were carried out with four concentrations - 24, 48, 91 and 130 μg/mL - of the essential oil, have shown a promising activity regarding the parameters under study. It was possible to notice a significant decline in the motility of the worms and a mortality rate of 100% 30 h after they had been exposed to the essential oil in the concentration of 130 μg/mL. Male worms were more susceptible, producing a dose-response effect within a smaller exposition period than female worms. In what refers to morphological changes, the essential oil of B. trimera induced a peeling on the tegument surface, as well as the destruction of tubercles and spines, which resulted in smooth areas on the body surface. The essential oil also caused tegument destruction in female worms, in addition to destruction of the oral and acetabular suckers. It is the first time that the schistosomicidal activity has been reported for essential oil of B. trimera (less) DC.
dc.description132
dc.description135-43
dc.languageeng
dc.relationExperimental Parasitology
dc.relationExp. Parasitol.
dc.rightsfechado
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBaccharis
dc.subjectBiomphalaria
dc.subjectCell Line
dc.subjectDose-response Relationship, Drug
dc.subjectFemale
dc.subjectGas Chromatography-mass Spectrometry
dc.subjectHumans
dc.subjectKeratinocytes
dc.subjectMale
dc.subjectMice
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMovement
dc.subjectOils, Volatile
dc.subjectOviposition
dc.subjectPlant Extracts
dc.subjectSchistosoma Mansoni
dc.subjectSchistosomiasis Mansoni
dc.subjectSchistosomicides
dc.subjectSex Factors
dc.subjectSpecific Pathogen-free Organisms
dc.titleSchistosoma Mansoni: In Vitro Schistosomicidal Activity Of Essential Oil Of Baccharis Trimera (less) Dc.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución