Oxidized Low-density Lipoproteins And Their Antibodies: Relationships With The Reverse Cholesterol Transport And Carotid Atherosclerosis In Adults Without Cardiovascular Diseases.

dc.creatorFerreira, Paolla F C
dc.creatorZago, Vanessa H S
dc.creatorD'Alexandri, Fabio L
dc.creatorPanzoldo, Natália B
dc.creatorGidlund, Magnus A
dc.creatorNakamura, Rui T
dc.creatorSchreiber, Roberto
dc.creatorParra, Eliane S
dc.creatorSantiago, Fernanda D
dc.creatorNakandakare, Edna R
dc.creatorQuintão, Eder C R
dc.creatorde Faria, Eliana C
dc.date2012-Oct
dc.date2015-11-27T13:28:34Z
dc.date2015-11-27T13:28:34Z
dc.date.accessioned2018-03-29T01:15:27Z
dc.date.available2018-03-29T01:15:27Z
dc.identifierClinica Chimica Acta; International Journal Of Clinical Chemistry. v. 413, n. 19-20, p. 1472-8, 2012-Oct.
dc.identifier1873-3492
dc.identifier10.1016/j.cca.2012.05.020
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22659061
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200032
dc.identifier22659061
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300265
dc.descriptionMetabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP, PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated. Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAI was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP. In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDL Ab and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role.
dc.description413
dc.description1472-8
dc.languageeng
dc.relationClinica Chimica Acta; International Journal Of Clinical Chemistry
dc.relationClin. Chim. Acta
dc.rightsfechado
dc.rightsCopyright © 2012 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis Of Variance
dc.subjectAntibodies
dc.subjectApolipoprotein B-100
dc.subjectBiological Transport
dc.subjectCarotid Arteries
dc.subjectCarotid Artery Diseases
dc.subjectCarotid Intima-media Thickness
dc.subjectCholesterol
dc.subjectCholesterol Ester Transfer Proteins
dc.subjectCholesterol, Ldl
dc.subjectFemale
dc.subjectHumans
dc.subjectLipase
dc.subjectLipoproteins, Ldl
dc.subjectLiver
dc.subjectMiddle Aged
dc.subjectPhospholipid Transfer Proteins
dc.subjectRisk Factors
dc.titleOxidized Low-density Lipoproteins And Their Antibodies: Relationships With The Reverse Cholesterol Transport And Carotid Atherosclerosis In Adults Without Cardiovascular Diseases.
dc.typeArtículos de revistas


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