Metastatic Mucinous Carcinomas In The Ovary: A Practical Approach To Diagnosis Related To Gross Aspects And To Immunohistochemical Evaluation.

dc.creatorPinto, Paola B Cardoso
dc.creatorDerchain, Sophie F M
dc.creatorAndrade, Liliana Aparecida Lucci De Angelo
dc.date2012-Jul
dc.date2015-11-27T13:28:34Z
dc.date2015-11-27T13:28:34Z
dc.date.accessioned2018-03-29T01:15:26Z
dc.date.available2018-03-29T01:15:26Z
dc.identifierInternational Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists. v. 31, n. 4, p. 313-8, 2012-Jul.
dc.identifier1538-7151
dc.identifier10.1097/PGP.0b013e31823f844d
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22653343
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200028
dc.identifier22653343
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300261
dc.descriptionOvarian mucinous carcinomas are uncommon, and the differential diagnosis is metastatic carcinoma mainly from the gastrointestinal tract. The aim was to verify the importance of immunohistochemical reactions and the algorithm described in literature on the basis of laterality and tumor size. Twenty-five cases identified as metastatic mucinous adenocarcinomas were reviewed, along with clinical records; a tissue microarray was created, and immunohistochemical reactions for CK7, CK20, Ca125, hormonal receptors, WT1, DPC4, β-catenin, and Cdx2 were determined. The median age was 51, and only 9 patients had a history of cancer. Sixteen patients (64%) had bilateral tumors, with sizes ranging from 5 to 36 cm (average, 20.5 cm); 9 (36%) had unilateral tumors varying from 5.5 to 38 cm (average, 21.8 cm). Algorithm agreement was 76%; most unilateral tumors were >13 cm. Common positive markers were Dpc4 (88%), Cdx2 (68%), CK20 (60%), and CK7 (44%). The useful markers were CK7, CK20, and Cdx2, although there were cases with overlapping results. The most common primary tumor was of colorectal origin (14 cases). The mean survival age was 32.6 mo. Although the proposed algorithm and immunohistochemical reactions are useful tools for diagnosis, some mucinous tumors cannot be definitively classified as primary or metastatic without further clinical evaluation, emphasizing the limits of this challenging diagnosis.
dc.description31
dc.description313-8
dc.languageeng
dc.relationInternational Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists
dc.relationInt. J. Gynecol. Pathol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdenocarcinoma, Mucinous
dc.subjectAdult
dc.subjectAged
dc.subjectAlgorithms
dc.subjectDiagnosis, Differential
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKaplan-meier Estimate
dc.subjectMiddle Aged
dc.subjectOvarian Neoplasms
dc.subjectRetrospective Studies
dc.subjectTissue Array Analysis
dc.subjectTumor Markers, Biological
dc.titleMetastatic Mucinous Carcinomas In The Ovary: A Practical Approach To Diagnosis Related To Gross Aspects And To Immunohistochemical Evaluation.
dc.typeArtículos de revistas


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