Hemodynamic Changes In Lipid Emulsion Therapy (smoflipid) For Bupivacaine Toxicity In Swines.

dc.creatorMelo, Marcos De Simone
dc.creatorBonfim, Matheus Rodrigues
dc.creatorDreyer, Elisabeth
dc.creatorBassanezi, Betina Silvia Beozzo
dc.creatorUdelsmann, Artur
dc.date2012-Apr
dc.date2015-11-27T13:28:28Z
dc.date2015-11-27T13:28:28Z
dc.date.accessioned2018-03-29T01:15:14Z
dc.date.available2018-03-29T01:15:14Z
dc.identifierActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 27, n. 4, p. 318-24, 2012-Apr.
dc.identifier1678-2674
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22534807
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199979
dc.identifier22534807
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300212
dc.descriptionTo evaluate the hemodynamic changes following SMOFlipid emulsion therapy with after bupivacaine intoxication in swines. Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, 5 mg.kg(-1) of bupivacaine by intravenous injection was administered and new hemodynamic measures were performed 1 minute later; the animals were than randomly divided into two groups and received 4 ml.kg(-1) of saline solution or 4 ml.kg(-1) of SMOFlipid emulsion 20%. Hemodynamic changes were then re-evaluated at 5, 10, 15, 20 and 30 minutes. Bupivacaine intoxication caused fall in arterial blood pressure, cardiac index, ventricular systolic work index mainly and no important changes in vascular resistances. SMOFlipid emulsion therapy was able to improve blood pressure mainly by increasing vascular resistance since the cardiac index had no significant improvement in our study. Hemodynamic results of the use of lipid emulsion in bupivacaine intoxication were better than the control group. The SMOFlipid emulsion is a option for reversing hypotension in cases of intoxication by bupivacaine.
dc.description27
dc.description318-24
dc.languageeng
dc.relationActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia
dc.relationActa Cir Bras
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnesthetics, Local
dc.subjectAnimals
dc.subjectBupivacaine
dc.subjectFat Emulsions, Intravenous
dc.subjectHemodynamics
dc.subjectSwine
dc.titleHemodynamic Changes In Lipid Emulsion Therapy (smoflipid) For Bupivacaine Toxicity In Swines.
dc.typeArtículos de revistas


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