Light Aerobic Physical Exercise In Combination With Leucine And/or Glutamine-rich Diet Can Improve The Body Composition And Muscle Protein Metabolism In Young Tumor-bearing Rats.

dc.creatorSalomão, Emilianne Miguel
dc.creatorGomes-Marcondes, Maria Cristina Cintra
dc.date2012-Dec
dc.date2015-11-27T13:28:22Z
dc.date2015-11-27T13:28:22Z
dc.date.accessioned2018-03-29T01:15:05Z
dc.date.available2018-03-29T01:15:05Z
dc.identifierJournal Of Physiology And Biochemistry. v. 68, n. 4, p. 493-501, 2012-Dec.
dc.identifier1877-8755
dc.identifier10.1007/s13105-012-0164-0
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22460363
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199938
dc.identifier22460363
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300171
dc.descriptionNutritional supplementation with some amino acids may influence host's responses and also certain mechanism involved in tumor progression. It is known that exercise influences body weight and muscle composition. Previous findings from our group have shown that leucine has beneficial effects on protein composition in cachectic rat model as the Walker 256 tumor. The main purpose of this study was to analyze the effects of light exercise and leucine and/or glutamine-rich diet in body composition and skeletal muscle protein synthesis and degradation in young tumor-bearing rats. Walker tumor-bearing rats were subjected to light aerobic exercise (swimming 30 min/day) and fed a leucine-rich (3%) and/or glutamine-rich (4%) diet for 10 days and compared to healthy young rats. The carcasses were analyzed as total water and fat body content and lean body mass. The gastrocnemious muscles were isolated and used for determination of total protein synthesis and degradation. The chemical body composition changed with tumor growth, increasing body water and reducing body fat content and total body nitrogen. After tumor growth, the muscle protein metabolism was impaired, showing that the muscle protein synthesis was also reduced and the protein degradation process was increased in the gastrocnemius muscle of exercised rats. Although short-term exercise (10 days) alone did not produce beneficial effects that would reduce tumor damage, host protein metabolism was improved when exercise was combined with a leucine-rich diet. Only total carcass nitrogen and protein were recovered by a glutamine-rich diet. Exercise, in combination with an amino acid-rich diet, in particular, leucine, had effects beyond reducing tumoral weight such as improving protein turnover and carcass nitrogen content in the tumor-bearing host.
dc.description68
dc.description493-501
dc.languageeng
dc.relationJournal Of Physiology And Biochemistry
dc.relationJ. Physiol. Biochem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCachexia
dc.subjectCarcinoma 256, Walker
dc.subjectDietary Supplements
dc.subjectExercise Therapy
dc.subjectGlutamine
dc.subjectLeucine
dc.subjectMale
dc.subjectNeoplasm Transplantation
dc.subjectPhysical Conditioning, Animal
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTumor Burden
dc.subjectWeight Gain
dc.titleLight Aerobic Physical Exercise In Combination With Leucine And/or Glutamine-rich Diet Can Improve The Body Composition And Muscle Protein Metabolism In Young Tumor-bearing Rats.
dc.typeArtículos de revistas


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