Chitosan-solid Lipid Nanoparticles As Carriers For Topical Delivery Of Tretinoin.

dc.creatorRidolfi, Daniela M
dc.creatorMarcato, Priscyla D
dc.creatorJusto, Giselle Z
dc.creatorCordi, Lívia
dc.creatorMachado, Daisy
dc.creatorDurán, Nelson
dc.date2012-May
dc.date2015-11-27T13:28:08Z
dc.date2015-11-27T13:28:08Z
dc.date.accessioned2018-03-29T01:14:43Z
dc.date.available2018-03-29T01:14:43Z
dc.identifierColloids And Surfaces. B, Biointerfaces. v. 93, p. 36-40, 2012-May.
dc.identifier1873-4367
dc.identifier10.1016/j.colsurfb.2011.11.051
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22244299
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199842
dc.identifier22244299
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300075
dc.descriptionTretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. The hydrodynamic mean diameter and zeta potential were 162.7±1.4 nm and -31.9±2.0 mV for SLN-TRE, and 284.8±15.0 nm and 55.9±3.1 mV for SLN-chitosan-TRE. The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acne.
dc.description93
dc.description36-40
dc.languageeng
dc.relationColloids And Surfaces. B, Biointerfaces
dc.relationColloids Surf B Biointerfaces
dc.rightsfechado
dc.rightsCopyright © 2011 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAcne Vulgaris
dc.subjectAdministration, Topical
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectChitosan
dc.subjectDrug Carriers
dc.subjectDrug Compounding
dc.subjectDrug Stability
dc.subjectHumans
dc.subjectKeratinocytes
dc.subjectLipids
dc.subjectMicrobial Sensitivity Tests
dc.subjectMicroscopy, Electron, Transmission
dc.subjectNanoparticles
dc.subjectParticle Size
dc.subjectPropionibacterium Acnes
dc.subjectStaphylococcus Aureus
dc.subjectTretinoin
dc.titleChitosan-solid Lipid Nanoparticles As Carriers For Topical Delivery Of Tretinoin.
dc.typeArtículos de revistas


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