Preliminary Assessment Of Cardiac Short Term Safety And Efficacy Of Manganese Chloride For Cardiovascular Magnetic Resonance In Humans.

dc.creatorFernandes, Juliano L
dc.creatorStorey, Pippa
dc.creatorda Silva, Jose Alvaro
dc.creatorde Figueiredo, Gabriel S
dc.creatorKalaf, Jose M
dc.creatorCoelho, Otavio R
dc.date2011
dc.date2015-11-27T13:22:18Z
dc.date2015-11-27T13:22:18Z
dc.date.accessioned2018-03-29T01:14:36Z
dc.date.available2018-03-29T01:14:36Z
dc.identifierJournal Of Cardiovascular Magnetic Resonance : Official Journal Of The Society For Cardiovascular Magnetic Resonance. v. 13, p. 6, 2011.
dc.identifier1532-429X
dc.identifier10.1186/1532-429X-13-6
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21235750
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199814
dc.identifier21235750
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300047
dc.descriptionManganese based agents are intracellular and accumulate inside myocytes allowing for different imaging strategies compared to gadolinium contrasts. While previous agents release manganese very slowly in the circulation, MnCl2 allows for rapid Mn2+ uptake in myocytes, creating a memory effect that can be potentially explored. Data on animal models are very encouraging but the safety and efficacy of this approach in humans has not yet been investigated. Therefore, our objectives were to study the safety and efficacy of a rapid infusion of manganese chloride (MnCl2) for cardiovascular magnetic resonance (CMR) in humans. Fifteen healthy volunteers underwent a CMR scan on a 1.5 T scanner. Before the infusion, cardiac function was calculated and images of a short axis mid-ventricular slice were obtained using a 2D and 3D gradient-echo inversion recovery (GRE-IR) sequence, a phase-sensitive IR sequence and a single breath-hold segmented IR prepared steady-state precession acquisition for T1 calculations. MnCl2 was infused over three minutes at a total dose of 5 μMol/kg. Immediately after the infusion, and at 15 and 30 minutes later, new images were obtained and cardiac function re-evaluated. There was a significant decrease in T1 values compared to baseline, sustained up to 30 minutes after the MnCl2 infusion (pre,839 ± 281 ms; 0 min, 684 ± 99; 15 min, 714 ± 168; 30 min, 706 ± 172, P = 0.003). The 2D and 3D GRE-IR sequence showed the greatest increase in signal-to-noise ratio compared to the other sequences (baseline 6.6 ± 4.2 and 9.7 ± 5.3; 0 min, 11.3 ± 4.1 and 15.0 ± 8.7; 15 min, 10.8 ± 4.0 and 16.9 ± 10.2; 30 min, 10.6 ± 5.2 and 16.5 ± 8.3, P < 0.001 for both). There was a slight increase in systolic pressure and heart rate after three and four minutes of the infusion with normalization of these parameters thereafter. Patients showed good tolerance to MnCl2 with no major adverse events, despite all reporting transient facial flush. In the short term, MnCl2 appears safe for human use. It effectively decreases myocardium T1, maintaining this effect for a relatively long period of time and allowing for the development of new imaging strategies in CMR, especially in ischemia research.
dc.description13
dc.description6
dc.languageeng
dc.relationJournal Of Cardiovascular Magnetic Resonance : Official Journal Of The Society For Cardiovascular Magnetic Resonance
dc.relationJ Cardiovasc Magn Reson
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectBlood Pressure
dc.subjectBrazil
dc.subjectChlorides
dc.subjectContrast Media
dc.subjectFemale
dc.subjectHeart
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectImage Interpretation, Computer-assisted
dc.subjectInfusions, Intravenous
dc.subjectMagnetic Resonance Imaging, Cine
dc.subjectMale
dc.subjectManganese Compounds
dc.subjectMiddle Aged
dc.subjectPilot Projects
dc.subjectPredictive Value Of Tests
dc.subjectProspective Studies
dc.subjectRisk Assessment
dc.subjectStroke Volume
dc.subjectTime Factors
dc.subjectVentricular Function, Left
dc.titlePreliminary Assessment Of Cardiac Short Term Safety And Efficacy Of Manganese Chloride For Cardiovascular Magnetic Resonance In Humans.
dc.typeArtículos de revistas


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