The Contribution Of Hypertension To Diabetic Nephropathy And Retinopathy: The Role Of Inflammation And Oxidative Stress.

dc.creatorLopes de Faria, José Butori
dc.creatorSilva, Kamila Cristina
dc.creatorLopes de Faria, Jacqueline Mendonça
dc.date2011-Apr
dc.date2015-11-27T13:22:18Z
dc.date2015-11-27T13:22:18Z
dc.date.accessioned2018-03-29T01:14:35Z
dc.date.available2018-03-29T01:14:35Z
dc.identifierHypertension Research : Official Journal Of The Japanese Society Of Hypertension. v. 34, n. 4, p. 413-22, 2011-Apr.
dc.identifier1348-4214
dc.identifier10.1038/hr.2010.263
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21228783
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199810
dc.identifier21228783
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300043
dc.descriptionDiabetes and hypertension frequently coexist and constitute the most notorious combination for the pathogenesis of diabetic nephropathy and retinopathy. Large clinical trials have clearly demonstrated that tight control of glycemia and/or blood pressure significantly reduces the incidence and progression of diabetic retinopathy (DR) and nephropathy. However, the mechanism by which hypertension interacts with diabetes to induce and/or exacerbate nephropathy and retinopathy is very unclear. Substantial evidence implicates the involvement of chronic inflammation and oxidative stress in the pathogenesis of DR and nephropathy. In addition, hypertension causes oxidative stress and inflammation in the kidney and retina. In the present review, we summarized data obtained from our research along with those from other groups to better understand the role of hypertension in the pathogenesis of diabetic nephropathy and retinopathy. It is suggested that oxidative stress and inflammation may be common denominators of kidney and retinal damage in the concomitant presence of diabetes and hypertension.
dc.description34
dc.description413-22
dc.languageeng
dc.relationHypertension Research : Official Journal Of The Japanese Society Of Hypertension
dc.relationHypertens. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectComorbidity
dc.subjectDiabetic Nephropathies
dc.subjectDiabetic Retinopathy
dc.subjectHumans
dc.subjectHypertension
dc.subjectInflammation
dc.subjectKidney
dc.subjectOxidative Stress
dc.subjectRetina
dc.titleThe Contribution Of Hypertension To Diabetic Nephropathy And Retinopathy: The Role Of Inflammation And Oxidative Stress.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución