Direct Monitoring Of Drug Degradation By Easy Ambient Sonic-spray Ionization Mass Spectrometry: The Case Of Enalapril.

dc.creatorAmaral, Phellipe H
dc.creatorFernandes, Raquel
dc.creatorEberlin, Marcos N
dc.creatorHöehr, Nelci F
dc.date2011-Dec
dc.date2015-11-27T13:22:06Z
dc.date2015-11-27T13:22:06Z
dc.date.accessioned2018-03-29T01:14:17Z
dc.date.available2018-03-29T01:14:17Z
dc.identifierJournal Of Mass Spectrometry : Jms. v. 46, n. 12, p. 1269-73, 2011-Dec.
dc.identifier1096-9888
dc.identifier10.1002/jms.2014
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22223418
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199724
dc.identifier22223418
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299957
dc.descriptionUsing enalapril maleate as a test case, the ability of ambient mass spectrometry, namely, via easy ambient sonic-spray ionization mass spectrometry (EASI-MS), to perform direct monitoring of drug degradation has been tested. Two manufacturing processes were investigated (direct compression and wet granulation), and the formation of degradation products was measured via both EASI-MS and high-performance liquid chromatography with ultraviolet detection for a total period of 18 months. Both techniques provide comparable results, which indicate that direct analysis by ambient mass spectrometric techniques presents a viable alternative for drug degradation monitoring with superior simplicity, throughput, and reliability (no sample manipulation), and comparable quantitative results. In terms of qualitative monitoring, the full mass spectra with intact species provided by EASI-MS allow for comprehensive monitoring of known and unknown (or unexpected) degradation products.
dc.description46
dc.description1269-73
dc.languageeng
dc.relationJournal Of Mass Spectrometry : Jms
dc.relationJ Mass Spectrom
dc.rightsfechado
dc.rightsCopyright © 2011 John Wiley & Sons, Ltd.
dc.sourcePubMed
dc.subjectDrug Stability
dc.subjectEnalapril
dc.subjectIons
dc.subjectSpectrometry, Mass, Electrospray Ionization
dc.titleDirect Monitoring Of Drug Degradation By Easy Ambient Sonic-spray Ionization Mass Spectrometry: The Case Of Enalapril.
dc.typeArtículos de revistas


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