Multifunctional Role Of Steroidogenic Factor 1 And Disorders Of Sex Development.

dc.creatorMello, Maricilda Palandi de
dc.creatorFrança, Emerson Salvador de Souza
dc.creatorFabbri, Helena Campos
dc.creatorMaciel-Guerra, Andréa Trevas
dc.creatorGuerra-Júnior, Gil
dc.date2011-Nov
dc.date2015-11-27T13:22:06Z
dc.date2015-11-27T13:22:06Z
dc.date.accessioned2018-03-29T01:14:15Z
dc.date.available2018-03-29T01:14:15Z
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. v. 55, n. 8, p. 607-12, 2011-Nov.
dc.identifier1677-9487
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22218443
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199722
dc.identifier22218443
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299955
dc.descriptionDisorders of sex development (DSD) involve several conditions that result from abnormalities during gonadal determination and differentiation. Some of these disorders may manifest at birth by ambiguous genitalia; others are diagnosed only at puberty, by the delayed onset of secondary sexual characteristics. Sex determination and differentiation in humans are processes that involve the interaction of several genes such as WT1, NR5A1, NR0B1, SOX9, among others, in the testicular pathway, and WNT4, DAX1, FOXL2 and RSPO1, in the ovarian pathway. One of the major proteins in mammalian gonadal differentiation is the steroidogenic nuclear receptor factor 1 (SF1). This review will cover some of the most recent data on SF1 functional roles and findings related to mutations in its coding gene, NR5A1.
dc.description55
dc.description607-12
dc.languageeng
dc.relationArquivos Brasileiros De Endocrinologia E Metabologia
dc.relationArq Bras Endocrinol Metabol
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectChild
dc.subjectDisorders Of Sex Development
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMutation
dc.subjectSteroidogenic Factor 1
dc.titleMultifunctional Role Of Steroidogenic Factor 1 And Disorders Of Sex Development.
dc.typeArtículos de revistas


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