Potential Utility Of Hyperbaric Oxygen Therapy And Propolis In Enhancing The Leishmanicidal Activity Of Glucantime.

dc.creatorAyres, Diana Copi
dc.creatorFedele, Thiago Antonio
dc.creatorMarcucci, Maria Cristina
dc.creatorGiorgio, Selma
dc.date
dc.date2015-11-27T13:22:05Z
dc.date2015-11-27T13:22:05Z
dc.date.accessioned2018-03-29T01:14:13Z
dc.date.available2018-03-29T01:14:13Z
dc.identifierRevista Do Instituto De Medicina Tropical De São Paulo. v. 53, n. 6, p. 329-34
dc.identifier1678-9946
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22183457
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199714
dc.identifier22183457
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299947
dc.descriptionIn this study we investigated the efficacy of hyperbaric oxygen (HBO) therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain) alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the lesion site; interferon-gamma (IFN-g) levels were not elevated in lymph node cells from these animals. Propain alone was not efficient against lesions, although less exudative lesions were observed in animals treated with propain alone or combined with glucantime. These results reveal the potential value of HBO and red propolis in combination with glucantime for treating cutaneous leishmaniasis and encourage further studies on the effect of more aggressive HBO, propolis and glucantime therapies on different mouse models of leishmaniasis.
dc.description53
dc.description329-34
dc.languageeng
dc.relationRevista Do Instituto De Medicina Tropical De São Paulo
dc.relationRev. Inst. Med. Trop. Sao Paulo
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntiprotozoal Agents
dc.subjectCombined Modality Therapy
dc.subjectDisease Models, Animal
dc.subjectHyperbaric Oxygenation
dc.subjectLeishmania Mexicana
dc.subjectLeishmaniasis, Cutaneous
dc.subjectMeglumine
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectOrganometallic Compounds
dc.subjectPropolis
dc.subjectTime Factors
dc.titlePotential Utility Of Hyperbaric Oxygen Therapy And Propolis In Enhancing The Leishmanicidal Activity Of Glucantime.
dc.typeArtículos de revistas


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