Characteristics Of Resistant Hypertension: Ageing, Body Mass Index, Hyperaldosteronism, Cardiac Hypertrophy And Vascular Stiffness.

dc.creatorMartins, L C
dc.creatorFigueiredo, V N
dc.creatorQuinaglia, T
dc.creatorBoer-Martins, L
dc.creatorYugar-Toledo, J C
dc.creatorMartin, J F V
dc.creatorDemacq, C
dc.creatorPimenta, E
dc.creatorCalhoun, D A
dc.creatorMoreno, H
dc.date2011-Sep
dc.date2015-11-27T13:21:36Z
dc.date2015-11-27T13:21:36Z
dc.date.accessioned2018-03-29T01:13:25Z
dc.date.available2018-03-29T01:13:25Z
dc.identifierJournal Of Human Hypertension. v. 25, n. 9, p. 532-8, 2011-Sep.
dc.identifier1476-5527
dc.identifier10.1038/jhh.2010.95
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20927128
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199509
dc.identifier20927128
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299742
dc.descriptionResistant hypertension (RHTN) includes patients whose blood pressure (BP) is controlled with the use of four or more antihypertensive medications, and is referred to as 'controlled resistant hypertension' (CRH). While specifically comparing patients with CRH and uncontrolled resistant hypertension (UCRH), we hoped to identify distinguishing characteristics that would provide insight into factors contributing to resistance to antihypertensive therapies. RHTN patients were identified as controlled (CRH, n=43) or uncontrolled (UCRH, n=47). No statistical differences were observed between the CRH and UCRH subgroups with respect to age and gender. The body mass index, aldosterone-renin ratio and pulse wave velocity (PWV) were significantly higher in UCRH patients. Although both subgroups showed increased cardiac mass, left ventricular mass index was significantly higher in UCRH compared with CRH patients. Multivariate linear regression analysis indicated that PWV was significantly dependent on age in both UCRH and CRH patients; however, the influence of ageing was more pronounced in the former subgroup. Older age, greater vascular stiffness, higher aldosterone levels and greater left ventricular hypertrophy were significantly associated with lack of BP control in patients with RHTN. These findings suggest important possibilities in terms of preventing and better treating RHTN.
dc.description25
dc.description532-8
dc.languageeng
dc.relationJournal Of Human Hypertension
dc.relationJ Hum Hypertens
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAged
dc.subjectAging
dc.subjectBody Mass Index
dc.subjectCardiomegaly
dc.subjectDrug Resistance
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperaldosteronism
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectVascular Stiffness
dc.titleCharacteristics Of Resistant Hypertension: Ageing, Body Mass Index, Hyperaldosteronism, Cardiac Hypertrophy And Vascular Stiffness.
dc.typeArtículos de revistas


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