Normalization Of Height And Excess Body Fat In Children With Salt-wasting 21-hydroxylase Deficiency.

dc.creatorMendes-Dos-Santos, Carolina T
dc.creatorLemos-Marini, Sofia H V
dc.creatorBaptista, Maria Tereza M
dc.creatorGuerra-Junior, Gil
dc.creatorDe-Mello, Maricilda P
dc.creatorPaulino, Maria Fernanda V M
dc.creatorMorcillo, André M
dc.date
dc.date2015-11-27T13:21:31Z
dc.date2015-11-27T13:21:31Z
dc.date.accessioned2018-03-29T01:13:18Z
dc.date.available2018-03-29T01:13:18Z
dc.identifierJornal De Pediatria. v. 87, n. 3, p. 263-8
dc.identifier1678-4782
dc.identifierdoi:10.2223/JPED.2095
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21660369
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199478
dc.identifier21660369
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299711
dc.descriptionTo evaluate growth and body composition of patients with the salt wasting form of classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency and to compare them with healthy children. Twenty-one prepubertal patients (eight boys and 13 girls) between 2.1 and 10.2 years and 67 prepubertal healthy controls (36 boys and 31 girls) between 1.2 and 11.7 years were included. Weight, height, upper-arm circumference, skinfolds, body composition determined by bioimpedance, and bone age were measured. The following data were obtained from the medical records: parents' height, serum levels of 17-hydroxyprogesterone and Δ4-androstenedione, prescribed hydrocortisone doses, weight and length at birth, in the beginning of the treatment, and at 2 years. Patients had lower weight and length z scores at the first appointment compared with the same data at birth, showing recovery after the beginning of the treatment without advanced bone age. Mean height z score was higher in controls (0.28 ± 0.86) than in patients (-0.61 ± 0.99, p < 0.001); this difference disappeared when the patients' height was adjusted to their bone age (0.33 ± 1.68, p = 0.912). Patients had higher body mass index (p < 0.001), fat mass (p < 0.001), and fat mass index (p < 0.001) than controls. There was no difference in the skinfolds between the two groups (p = 0.157). Patients had growth recovery with mean height similar to the general population; however, they had higher body fat, which seems to be visceral, since there was no difference between the skinfolds of both groups.
dc.description87
dc.description263-8
dc.languageeng
dc.languagepor
dc.relationJornal De Pediatria
dc.relationJ Pediatr (Rio J)
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdipose Tissue
dc.subjectAdrenal Hyperplasia, Congenital
dc.subjectAnti-inflammatory Agents
dc.subjectBody Composition
dc.subjectBody Height
dc.subjectBody Mass Index
dc.subjectBone Development
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEpidemiologic Methods
dc.subjectFemale
dc.subjectGrowth
dc.subjectHumans
dc.subjectHydrocortisone
dc.subjectInfant
dc.subjectMale
dc.subjectSkinfold Thickness
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.titleNormalization Of Height And Excess Body Fat In Children With Salt-wasting 21-hydroxylase Deficiency.
dc.typeArtículos de revistas


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