Indigofera Suffruticosa Mill As New Source Of Healing Agent: Involvement Of Prostaglandin And Mucus And Heat Shock Proteins.

dc.creatorLuiz-Ferreira, Anderson
dc.creatorCola, Maira
dc.creatorBarbastefano, Victor
dc.creatorFarias-Silva, Elisangela
dc.creatorCalvo, Tamara Regina
dc.creatorde Almeida, Ana Beatriz Albino
dc.creatorPellizzon, Claudia Helena
dc.creatorHiruma-Lima, Clélia Akiko
dc.creatorVilegas, Wagner
dc.creatorSouza-Brito, Alba Regina Monteiro
dc.date2011-Sep
dc.date2015-11-27T13:21:27Z
dc.date2015-11-27T13:21:27Z
dc.date.accessioned2018-03-29T01:13:10Z
dc.date.available2018-03-29T01:13:10Z
dc.identifierJournal Of Ethnopharmacology. v. 137, n. 1, p. 192-8, 2011-Sep.
dc.identifier1872-7573
dc.identifier10.1016/j.jep.2011.05.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21600972
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199440
dc.identifier21600972
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299673
dc.descriptionIndigofera suffruticosa is specie typical of the Cerrado or Brazilian savannah; it is a member of the Fabaceae family - in folkmedicine is used for gastric disorders, infection and inflammation. Ethyl acetate fraction (AcF) and aqueous fraction (AqF) of the methanolic extract of I. suffruticosa leaves were evaluated against acute gastric ulcer. The AcF fraction was selected to assess its activity in ulcer healing and its gastroprotective effects via mucus and gastric secretion. The gastroprotective action of AcF and AqF fractions were evaluated in a rodent experimental model. The action mechanisms, involvements of the antisecretory action, mucus and prostaglandin production, toxicological and healing activity of the AcF (100mg/kg, p.o.) were evaluated. We also used histological analysis (HE and PAS) and immunohistochemical (PCNA and HSP-70) assays to evaluate the effects of I. suffruticosa. AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant in 100mg/kg group compared vehicle. AcF did not interfered with gastric secretion, significantly increased the PGE(2) and mucus production (validated in PAS technique). The gastroprotection was attenuated by pretreatment with N-ethylmaleimide, but not L-NAME. In acid-acetic-induced ulcer model AcF accelerated ulcer healing. Immunohistochemistry analysis showed induction of proliferating cell (PCNA) and heat shock protein (HSP 70). These results showed that AcF acted as gastroprotective agent stimulating prostaglandin, mucus and HSP70.
dc.description137
dc.description192-8
dc.languageeng
dc.relationJournal Of Ethnopharmacology
dc.relationJ Ethnopharmacol
dc.rightsfechado
dc.rightsCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
dc.sourcePubMed
dc.subjectAcetates
dc.subjectAnimals
dc.subjectAnti-ulcer Agents
dc.subjectCytoprotection
dc.subjectDisease Models, Animal
dc.subjectEthanol
dc.subjectHsp70 Heat-shock Proteins
dc.subjectImmunohistochemistry
dc.subjectIndigofera
dc.subjectMale
dc.subjectMethanol
dc.subjectMucus
dc.subjectNitric Oxide
dc.subjectPlant Extracts
dc.subjectProliferating Cell Nuclear Antigen
dc.subjectProstaglandins
dc.subjectRats
dc.subjectSolvents
dc.subjectStomach
dc.subjectStomach Ulcer
dc.subjectSulfhydryl Compounds
dc.subjectWater
dc.subjectWound Healing
dc.titleIndigofera Suffruticosa Mill As New Source Of Healing Agent: Involvement Of Prostaglandin And Mucus And Heat Shock Proteins.
dc.typeArtículos de revistas


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