Chemical Profile Of Meta-chlorophenylpiperazine (m-cpp) In Ecstasy Tablets By Easy Ambient Sonic-spray Ionization, X-ray Fluorescence, Ion Mobility Mass Spectrometry And Nmr.

dc.creatorRomão, Wanderson
dc.creatorLalli, Priscila M
dc.creatorFranco, Marcos F
dc.creatorSanvido, Gustavo
dc.creatorSchwab, Nicolas V
dc.creatorLanaro, Rafael
dc.creatorCosta, José Luiz
dc.creatorSabino, Bruno D
dc.creatorBueno, Maria Izabel M S
dc.creatorde Sa, Gilberto F
dc.creatorDaroda, Romeu J
dc.creatorde Souza, Vanderlea
dc.creatorEberlin, Marcos N
dc.date2011-Jul
dc.date2015-11-27T13:21:15Z
dc.date2015-11-27T13:21:15Z
dc.date.accessioned2018-03-29T01:12:52Z
dc.date.available2018-03-29T01:12:52Z
dc.identifierAnalytical And Bioanalytical Chemistry. v. 400, n. 9, p. 3053-64, 2011-Jul.
dc.identifier1618-2650
dc.identifier10.1007/s00216-011-4883-9
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21475947
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199363
dc.identifier21475947
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299596
dc.descriptionMeta-chlorophenylpiperazine (m-CPP) is a new illicit drug that has been sold as ecstasy tablets. Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) and X-ray fluorescence spectrometry (XRF) are shown to provide relatively simple and selective screening tools to distinguish m-CPP tablets from tablets containing amphetamines (mainly 3,4-methylenedioxymethamphetamine (MDMA)). EASI-MS detects the active ingredients in their protonated forms: [m-CPP + H](+) of m/z 197, [MDMA + H](+) of m/z 194, and [2MDMA + HCl + H](+) of m/z 423 and other ions from excipients directly on the tablet surface, providing distinct chemical fingerprints. XRF identifies Cl, K, Ca, Fe, and Cu as inorganic ingredients present in the m-CPP tablets. In contrast, higher Cl concentrations and a more diverse set of elements (P, Cl, Ca, Fe, Cu, Zn, Pt, V, Hf, Ti, Pt, and Zr) were found in MDMA tablets. Principal component analysis applied to XRF data arranged samples in three groups: m-CPP tablets (four samples), MDMA tablets (twenty three samples), and tablets with no active ingredients (three samples). The EASI-MS and XRF techniques were also evaluated to quantify m-CPP in ecstasy tablets, with concentrations ranging from 4 to 40 mg of m-CPP per tablets. The m-CPP could only be differentiated from its isomers (o-CPP and for the three isomers p-CPP) by traveling wave ion mobility mass spectrometry and NMR measurements.
dc.description400
dc.description3053-64
dc.languageeng
dc.relationAnalytical And Bioanalytical Chemistry
dc.relationAnal Bioanal Chem
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.titleChemical Profile Of Meta-chlorophenylpiperazine (m-cpp) In Ecstasy Tablets By Easy Ambient Sonic-spray Ionization, X-ray Fluorescence, Ion Mobility Mass Spectrometry And Nmr.
dc.typeArtículos de revistas


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