Prilocaine-cyclodextrin-liposome: Effect Of Ph Variations On The Encapsulation And Topology Of A Ternary Complex Using 1h Nmr.

dc.creatorCabeça, Luís Fernando
dc.creatorFigueiredo, Isis Martins
dc.creatorde Paula, Eneida
dc.creatorMarsaioli, Anita Jocelyne
dc.date2011-Jun
dc.date2015-11-27T13:21:14Z
dc.date2015-11-27T13:21:14Z
dc.date.accessioned2018-03-29T01:12:50Z
dc.date.available2018-03-29T01:12:50Z
dc.identifierMagnetic Resonance In Chemistry : Mrc. v. 49, n. 6, p. 295-300, 2011-Jun.
dc.identifier1097-458X
dc.identifier10.1002/mrc.2740
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21452355
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199354
dc.identifier21452355
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299587
dc.descriptionA better comprehension of the prilocaine (PLC)-β-cyclodextrin (β-CD) complex liberation to membranes was provided by studying the architectural supramolecular arrangements of PLC, β-CD and egg phosphatidylcholine (EPC) liposomes, a membrane model. The topologies and possible interactions of mixtures of PLC, β-CD and EPC liposomes were investigated by nuclear magnetic resonances combining experimental (1)H-NMR (1D ROESY, STD and DOSY) at different pHs. The results indicate that in the mixture PLC/β-CD/EPC at pH 10 the PLC molecules are almost totally embedded into the liposomes and little interaction was observed between PLC and β-CD. However, at pH 5.5 not only was PLC imbedded in the EPC bilayer, but PLC was also interacting with β-CD. These results were rationalized as a spontaneous PLC release from β-CD to liposomes vesicles, whereas the PLC/EPC complex formation was higher at pH 10 than pH 5.5.
dc.description49
dc.description295-300
dc.languageeng
dc.relationMagnetic Resonance In Chemistry : Mrc
dc.relationMagn Reson Chem
dc.rightsfechado
dc.rightsCopyright © 2011 John Wiley & Sons, Ltd.
dc.sourcePubMed
dc.subjectEggs
dc.subjectHydrogen-ion Concentration
dc.subjectLiposomes
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMolecular Structure
dc.subjectPhosphatidylcholines
dc.subjectPrilocaine
dc.subjectProtons
dc.subjectReference Standards
dc.subjectBeta-cyclodextrins
dc.titlePrilocaine-cyclodextrin-liposome: Effect Of Ph Variations On The Encapsulation And Topology Of A Ternary Complex Using 1h Nmr.
dc.typeArtículos de revistas


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