Calcium-binding Proteins In Skeletal Muscles Of The Mdx Mice: Potential Role In The Pathogenesis Of Duchenne Muscular Dystrophy.

dc.creatorPertille, Adriana
dc.creatorde Carvalho, Candida Luiza Tonizza
dc.creatorMatsumura, Cintia Yuri
dc.creatorNeto, Humberto Santo
dc.creatorMarques, Maria Julia
dc.date2010-Feb
dc.date2015-11-27T13:18:37Z
dc.date2015-11-27T13:18:37Z
dc.date.accessioned2018-03-29T01:12:18Z
dc.date.available2018-03-29T01:12:18Z
dc.identifierInternational Journal Of Experimental Pathology. v. 91, n. 1, p. 63-71, 2010-Feb.
dc.identifier1365-2613
dc.identifier10.1111/j.1365-2613.2009.00688.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20002835
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199220
dc.identifier20002835
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299453
dc.descriptionDuchenne muscular dystrophy is one of the most common hereditary diseases. Abnormal ion handling renders dystrophic muscle fibers more susceptible to necrosis and a rise in intracellular calcium is an important initiating event in dystrophic muscle pathogenesis. In the mdx mice, muscles are affected with different intensities and some muscles are spared. We investigated the levels of the calcium-binding proteins calsequestrin and calmodulin in the non-spared axial (sternomastoid and diaphragm), limb (tibialis anterior and soleus), cardiac and in the spared extraocular muscles (EOM) of control and mdx mice. Immunoblotting analysis showed a significant increase of the proteins in the spared mdx EOM and a significant decrease in the most affected diaphragm. Both proteins were comparable to the cardiac muscle controls. In limb and sternomastoid muscles, calmodulin and calsequestrin were affected differently. These results suggest that differential levels of the calcium-handling proteins may be involved in the pathogenesis of myonecrosis in mdx muscles. Understanding the signaling mechanisms involving Ca(2+)-calmodulin activation and calsequestrin expression may be a valuable way to develop new therapeutic approaches to the dystrophinopaties.
dc.description91
dc.description63-71
dc.languageeng
dc.relationInternational Journal Of Experimental Pathology
dc.relationInt J Exp Pathol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlotting, Western
dc.subjectCalmodulin
dc.subjectCalsequestrin
dc.subjectDiaphragm
dc.subjectDisease Models, Animal
dc.subjectFluorescent Antibody Technique
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Mdx
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophy, Duchenne
dc.subjectMyocardium
dc.subjectNecrosis
dc.subjectPhenotype
dc.titleCalcium-binding Proteins In Skeletal Muscles Of The Mdx Mice: Potential Role In The Pathogenesis Of Duchenne Muscular Dystrophy.
dc.typeArtículos de revistas


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