Optional Screening Strategies For Cervical Cancer Using Standalone Tests And Their Combinations Among Low- And Medium-income Populations In Latin America And Eastern Europe.

dc.creatorSarian, Luis Otavio
dc.creatorDerchain, Sophie
dc.creatorShabalova, Irena
dc.creatorTatti, Silvio
dc.creatorNaud, Paulo
dc.creatorLongatto-Filho, Adhemar
dc.creatorSyrjänen, Stina
dc.creatorSyrjänen, Kari
dc.creator,
dc.date2010
dc.date2015-11-27T13:18:28Z
dc.date2015-11-27T13:18:28Z
dc.date.accessioned2018-03-29T01:12:02Z
dc.date.available2018-03-29T01:12:02Z
dc.identifierJournal Of Medical Screening. v. 17, n. 4, p. 195-203, 2010.
dc.identifier1475-5793
dc.identifier10.1258/jms.2010.010016
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21258130
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199150
dc.identifier21258130
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299383
dc.descriptionThe performance of cervical cancer (CC) screening can be improved by combining Pap smear with human papillomavirus (HPV) testing or visual methods, addressing local demographic, clinical and economic characteristics. To examine the performance of standalone and combined screening tools in populations with variable prevalence of cervical intraepithelial neoplasia (CIN) and CC. Merged data-sets from the Latin American Screening Study and New Independent States cohorts provided results for 15,000 women, screened using Pap smear, HPV testing and visual inspection with acetic acid, in Brazil, Argentina, Russia, Belarus and Latvia. Bayesian correction for verification bias was used. At CIN2+ cut-off, HPV detection alone was the most sensitive technique. There was an improvement (88.5% to 92.7%) in Hybrid Capture 2 (HC2) sensitivity among women ≥35 years old. Using HPV detection alone was the least specific screening tool, regardless of the age group (69.9% [95% CI 66.5-72.8%] and 86.4% [95% CI 84.6-88.2%], in < or ≥35 years, respectively). Of the test combinations, Pap smear (LSIL threshold) with HC2 had the highest specificity (98.7%; 95% CI 98.3-99.0%). However, in women ≥35 years, the sensitivity of Pap alone was superior to that of the combination. The Pap test is a highly specific screening option in populations with medium-range CC prevalence. Combined testing for HPV in this scenario may yield slightly better positive predictive values in women ≥35 years of age with LSIL, but at a high incremental cost.
dc.description17
dc.description195-203
dc.languageeng
dc.relationJournal Of Medical Screening
dc.relationJ Med Screen
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectEurope, Eastern
dc.subjectFemale
dc.subjectHumans
dc.subjectLatin America
dc.subjectMass Screening
dc.subjectMiddle Aged
dc.subjectPapanicolaou Test
dc.subjectPapillomavirus Infections
dc.subjectSensitivity And Specificity
dc.subjectUterine Cervical Neoplasms
dc.subjectVaginal Smears
dc.subjectYoung Adult
dc.titleOptional Screening Strategies For Cervical Cancer Using Standalone Tests And Their Combinations Among Low- And Medium-income Populations In Latin America And Eastern Europe.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución