Chlorella Vulgaris Modulates Immunomyelopoietic Activity And Enhances The Resistance Of Tumor-bearing Mice.

dc.creatorRamos, Aline Lisie
dc.creatorTorello, Cristiane Okuda
dc.creatorQueiroz, Mary L S
dc.date2010
dc.date2015-11-27T13:18:21Z
dc.date2015-11-27T13:18:21Z
dc.date.accessioned2018-03-29T01:11:48Z
dc.date.available2018-03-29T01:11:48Z
dc.identifierNutrition And Cancer. v. 62, n. 8, p. 1170-80, 2010.
dc.identifier1532-7914
dc.identifier10.1080/01635581.2010.513801
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21058206
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199090
dc.identifier21058206
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299323
dc.descriptionWe studied the effects of Chlorella vulgaris (CV) on the interaction between stromal and hematopoietic stem cells in normal and Ehrlich ascites tumor (EAT)-bearing mice. Long-term bone marrow culture (LTBMC), cytokine production, spleen mononuclear cells (SMC) proliferation (SCP), colony stimulating activity (CSA), and NK cells activity were evaluated. In tumor bearers, reduced capacity of stromal cell layer to support the growth and differentiation of granulocyte-macrophage progenitor cells (CFU-GM), concomitantly to decreased numbers of total nonadherent cells in LTBMC and reduced local production of IL-6 and IL-1α, were observed. Presence of the tumor has not altered the number of stromal adherent cells. CV treatment restored the ability of stromal cells from EAT-bearing mice to produce IL-6 and IL-1α, which was consistent with increased number of nonadherent cells and higher ability to display CFU-GM in vitro. EAT growth increased SCP, serum CSA, and IL-10 production and concurrently depressed NK cell activity and the secretion of IL-2, IFN-γ, and TNF-α. Treatment of tumor-bearing mice with CV augmented CSA, SMC proliferation, NK cell activity, and the production of IL-2, IFN-γ, and TNF-α, whereas IL-10 levels where reduced. Our results suggest that CV modulates immunehematopoietic cell activity and disengages tumor-induced suppression of these responses.
dc.description62
dc.description1170-80
dc.languageeng
dc.relationNutrition And Cancer
dc.relationNutr Cancer
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectBone Marrow Cells
dc.subjectCarcinoma, Ehrlich Tumor
dc.subjectCell Differentiation
dc.subjectCell Proliferation
dc.subjectCells, Cultured
dc.subjectChlorella Vulgaris
dc.subjectColony-stimulating Factors
dc.subjectCytokines
dc.subjectDietary Supplements
dc.subjectGranulocyte-macrophage Progenitor Cells
dc.subjectHematopoietic Stem Cells
dc.subjectImmunologic Factors
dc.subjectKiller Cells, Natural
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMyelopoiesis
dc.subjectPhytotherapy
dc.subjectSpecific Pathogen-free Organisms
dc.subjectSpleen
dc.subjectStromal Cells
dc.titleChlorella Vulgaris Modulates Immunomyelopoietic Activity And Enhances The Resistance Of Tumor-bearing Mice.
dc.typeArtículos de revistas


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