Proliferative, Structural And Molecular Features Of The Mdx Mouse Prostate.

dc.creatorPinto, Leslie C
dc.creatorFávaro, Wagner J
dc.creatorCagnon, Valéria H A
dc.date2010-Oct
dc.date2015-11-27T13:18:03Z
dc.date2015-11-27T13:18:03Z
dc.date.accessioned2018-03-29T01:11:15Z
dc.date.available2018-03-29T01:11:15Z
dc.identifierInternational Journal Of Experimental Pathology. v. 91, n. 5, p. 408-19, 2010-Oct.
dc.identifier1365-2613
dc.identifier10.1111/j.1365-2613.2010.00722.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20618884
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198943
dc.identifier20618884
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299176
dc.descriptionThe prostate is fundamental to the male reproductive process, and the stroma-epithelium interaction has an important role in prostate maintenance. Studies suggest that dystroglycan (DG) plays a role in cancer development in various organs. Thus, the aims of this work were to characterize morphological and proliferative features of the prostatic stroma and epithelium of mdx mice; to verify the immunolocalization of the α and β DG, IGF-1 and laminin α3 receptors; and to relate those structural and molecular events to prostate pathogenesis and to verify the viability of this experimental model in prostate studies. Thirty male mice (mdx and C57BL10/Uni) were divided into control and mdx groups. Samples from the ventral prostate were collected for immunological, Western Blotting, transmission electron microscopy and morphometric analyses. Oestradiol and testosterone measurements were verified. The results showed diminished testosterone and increased oestradiol levels in the mdx group. Atrophied cells and hypertrophied stroma were seen in the mdx mice. Weak α and β DG and laminin α3 immunolocalization was demonstrated in the mdx group. Intense insulin-like growth factor receptor α-1 (IGFRα-1) localization was identified in the mdx animals. Thus, mdx animals showed changes in molecular and structural integrity and proliferation signals, leading to glandular homoeostasis imbalance, and compromise of prostate function. Also, the steroid hormone imbalance and the increased IGF-1 receptor level detected in mdx mice could be considered as a crucial factor in the pathogenesis of prostatic disorders.
dc.description91
dc.description408-19
dc.languageeng
dc.relationInternational Journal Of Experimental Pathology
dc.relationInt J Exp Pathol
dc.rightsfechado
dc.rights© 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCell Division
dc.subjectDisease Models, Animal
dc.subjectDystroglycans
dc.subjectEstradiol
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectMicroscopy, Electron, Transmission
dc.subjectMuscular Dystrophy, Animal
dc.subjectProstate
dc.subjectProstatic Diseases
dc.subjectTestosterone
dc.titleProliferative, Structural And Molecular Features Of The Mdx Mouse Prostate.
dc.typeArtículos de revistas


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