Involvement Of Temporomandibular Joint P2x3 And P2x2/3 Receptors In Carrageenan-induced Inflammatory Hyperalgesia In Rats.

dc.creatorTeixeira, Juliana Maia
dc.creatorOliveira, Maria Cláudia G
dc.creatorNociti, F H
dc.creatorClemente-Napimoga, J T
dc.creatorPelegrini-da-Silva, Adriana
dc.creatorParada, Carlos Amílcar
dc.creatorTambeli, Cláudia Herrera
dc.date2010-Oct
dc.date2015-11-27T13:17:58Z
dc.date2015-11-27T13:17:58Z
dc.date.accessioned2018-03-29T01:11:06Z
dc.date.available2018-03-29T01:11:06Z
dc.identifierEuropean Journal Of Pharmacology. v. 645, n. 1-3, p. 79-85, 2010-Oct.
dc.identifier1879-0712
dc.identifier10.1016/j.ejphar.2010.06.008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20558155
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198906
dc.identifier20558155
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299139
dc.descriptionThe aim of this study was to investigate the role of P2X3, P2X2/3 and P2X7 receptors in the development of TMJ hyperalgesia induced by carrageenan. We also investigated the expression of mRNA of P2X7 receptors in the trigeminal ganglia and the existence of functional P2X7 receptors in the rat's TMJ. The P2X1, P2X3 and P2X2/3 receptor antagonist TNP-ATP, but not the selective P2X7 receptor antagonist A-438079, significantly reduced carrageenan-induced TMJ inflammatory hyperalgesia. The qPCR assay showed that mRNA of P2X7 receptors are expressed in the trigeminal ganglia but this expression is not increased by the inflammation induced by carrageenan in the TMJ region. The P2X7 receptor agonist BzATP induced TMJ inflammatory hyperalgesia that was significantly reduced by pretreatment with dexamethasone. These results indicate that P2X3 and P2X2/3 but not P2X7 receptors are involved in carrageenan-induced TMJ inflammatory hyperalgesia. However, functional P2X7 receptors are expressed in the TMJ region. The activation of these receptors by BzATP sensitizes the primary afferent nociceptors in the TMJ through the previous release of inflammatory mediators. The findings of this study point out P2X3 and P2X2/3 receptors, but not P2X7 receptors, as potential targets for the development of new analgesic drugs to control TMJ inflammatory pain.
dc.description645
dc.description79-85
dc.languageeng
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightsCopyright 2010 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAdenosine Triphosphate
dc.subjectAnimals
dc.subjectCarrageenan
dc.subjectHyperalgesia
dc.subjectInflammation
dc.subjectMale
dc.subjectPurinergic P2x Receptor Agonists
dc.subjectPurinergic P2x Receptor Antagonists
dc.subjectPyridines
dc.subjectRna, Messenger
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Purinergic P2
dc.subjectReceptors, Purinergic P2x2
dc.subjectReceptors, Purinergic P2x3
dc.subjectReceptors, Purinergic P2x7
dc.subjectTemporomandibular Joint
dc.subjectTetrazoles
dc.subjectTrigeminal Ganglion
dc.titleInvolvement Of Temporomandibular Joint P2x3 And P2x2/3 Receptors In Carrageenan-induced Inflammatory Hyperalgesia In Rats.
dc.typeArtículos de revistas


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