Liposomal Encapsulation Improves The Duration Of Soft Tissue Anesthesia But Does Not Induce Pulpal Anesthesia.

dc.creatorFranz-Montan, Michelle
dc.creatorSilva, André L R
dc.creatorFraceto, Leonardo F
dc.creatorVolpato, Maria C
dc.creatorPaula, Eneida de
dc.creatorRanali, José
dc.creatorGroppo, Francisco C
dc.date2010-Aug
dc.date2015-11-27T13:17:57Z
dc.date2015-11-27T13:17:57Z
dc.date.accessioned2018-03-29T01:11:04Z
dc.date.available2018-03-29T01:11:04Z
dc.identifierJournal Of Clinical Anesthesia. v. 22, n. 5, p. 313-7, 2010-Aug.
dc.identifier1873-4529
dc.identifier10.1016/j.jclinane.2010.03.001
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20542419
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198897
dc.identifier20542419
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299130
dc.descriptionTo compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulations. Double-blinded, randomized crossover study. University ambulatory dental center. 30 ASA physical status I volunteers. Volunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal fold. Pain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded. Pulpal anesthesia was evaluated using an electric pulp tester. VAS values (median, 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 - 21) for B10, LB10, and B20, respectively. No differences were noted among the groups (Friedman test; P = 0.58). Soft tissue anesthesia was also not different. The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test; P < 0.01) than the other agents [B10 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min]. None of the topical benzocaine formulations tested induced pulpal anesthesia. The encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia. However, it did not induce pulpal anesthesia.
dc.description22
dc.description313-7
dc.languageeng
dc.relationJournal Of Clinical Anesthesia
dc.relationJ Clin Anesth
dc.rightsfechado
dc.rightsCopyright 2010 Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAdministration, Topical
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnesthesia, Dental
dc.subjectAnesthesia, Local
dc.subjectAnesthetics, Local
dc.subjectBenzocaine
dc.subjectCross-over Studies
dc.subjectDental Pulp
dc.subjectDouble-blind Method
dc.subjectFemale
dc.subjectGels
dc.subjectHumans
dc.subjectLiposomes
dc.subjectMale
dc.subjectMouth Mucosa
dc.subjectPain Measurement
dc.subjectTime Factors
dc.subjectYoung Adult
dc.titleLiposomal Encapsulation Improves The Duration Of Soft Tissue Anesthesia But Does Not Induce Pulpal Anesthesia.
dc.typeArtículos de revistas


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