A Novel Association Of Acquired Adamts13 Inhibitor And Acute Dengue Virus Infection.

dc.creatorRossi, Fernanda C
dc.creatorAngerami, Rodrigo N
dc.creatorde Paula, Erich V
dc.creatorOrsi, Fernanda L
dc.creatorShang, Dezhi
dc.creatordel Guercio, Vânia M
dc.creatorResende, Mariângela R
dc.creatorAnnichino-Bizzacchi, Joyce M
dc.creatorda Silva, Luiz J
dc.creatorZheng, X Long
dc.creatorCastro, Vagner
dc.date2010-Jan
dc.date2015-11-27T13:17:56Z
dc.date2015-11-27T13:17:56Z
dc.date.accessioned2018-03-29T01:11:02Z
dc.date.available2018-03-29T01:11:02Z
dc.identifierTransfusion. v. 50, n. 1, p. 208-12, 2010-Jan.
dc.identifier1537-2995
dc.identifier10.1111/j.1537-2995.2009.02391.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19788513
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198891
dc.identifier19788513
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299124
dc.descriptionDengue is a mosquito-borne viral disease with an increasing incidence worldwide. Thrombocytopenia is a common finding in dengue virus (DV) infection; however, the underlying mechanisms remain unknown. Here we provide the first evidence of a case of antibody formation against ADAMTS13 (ADAMTS13 inhibitor) in the course of a severe acute DV infection resulting in thrombotic microangiopathy (TMA). The patient presented with classical dengue symptoms (positive epidemiology, high fever, myalgia, predominantly in the lower limbs and lumbar region for 1 week) and, after 11 days of initial symptoms, developed TMA. Clinical and laboratorial investigation of dengue and TMA was performed. The patient presented with ADAMTS13 inhibitor (IgG) during the acute phase of the disease, without anti-platelet antibodies detectable. Dengue infection had laboratorial confirmation. There were excellent clinical and laboratory responses to 11 serial plasma exchanges. Anti-ADAMTS13 inhibitor disappeared after remission of TMA and dengue resolution. No recurrence of TMA symptoms was observed after 2-year follow-up. Although the real incidence of dengue-related TMA is unknown, this case provides the basis for future epidemiologic studies on acquired ADAMTS13 deficiency in DV infection. The prompt clinical recognition of this complication and early installment of specific therapy with plasma exchange are likely to improve the outcome of severe cases of dengue.
dc.description50
dc.description208-12
dc.languageeng
dc.relationTransfusion
dc.relationTransfusion
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdam Proteins
dc.subjectAcute Disease
dc.subjectAutoantibodies
dc.subjectBlood Platelets
dc.subjectDengue
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPlasma Exchange
dc.subjectThrombotic Microangiopathies
dc.titleA Novel Association Of Acquired Adamts13 Inhibitor And Acute Dengue Virus Infection.
dc.typeArtículos de revistas


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