Cd10 (neutral Endopeptidase) Expression In Myoepithelial Cells Of Salivary Neoplasms.

dc.creatorNeves, Catarina de Oliveira
dc.creatorSoares, Andresa Borges
dc.creatorCosta, Ana Flávia
dc.creatorde Araujo, Vera Cavalcanti
dc.creatorFuruse, Cristiane
dc.creatorJuliano, Priscila Bianchi
dc.creatorAltemani, Albina
dc.date2010-Mar
dc.date2015-11-27T13:17:51Z
dc.date2015-11-27T13:17:51Z
dc.date.accessioned2018-03-29T01:10:53Z
dc.date.available2018-03-29T01:10:53Z
dc.identifierApplied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication Of The Society For Applied Immunohistochemistry. v. 18, n. 2, p. 172-8, 2010-Mar.
dc.identifier1533-4058
dc.identifier10.1097/PAI.0b013e3181b8f7c5
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19752720
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198847
dc.identifier19752720
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299080
dc.descriptionCD10 is a cell surface peptidase expressed in a wide variety of normal and neoplastic tissues, including breast myoepithelial cells. In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas. However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed. We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10. In salivary glands, CD10 expression was not detected in myoepithelial cells. Only fibrocytes within the intralobular stroma were CD10 positive. In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms. When the different groups of tumors were compared, epithelial-myoepithelial carcinomas (EMEC) showed a stark contrast with the others (83.3% of cases with CD10 expression). Surprisingly, adenoid cystic carcinomas and basal cell adenomas were negative in 100% of the cases. Myoepitheliomas, pleomorphic adenomas, and myoepithelial carcinomas were positive in 27.7%, 30.0%, and 40% of the cases, respectively. In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts. However, the gain of this protein is not a sensitive marker for detecting myoepithelial cells in the majority of the tumors, except for EMEC. The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible.
dc.description18
dc.description172-8
dc.languageeng
dc.relationApplied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication Of The Society For Applied Immunohistochemistry
dc.relationAppl. Immunohistochem. Mol. Morphol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectActins
dc.subjectAged
dc.subjectCell Differentiation
dc.subjectCell Transformation, Neoplastic
dc.subjectDiagnosis, Differential
dc.subjectDisease Progression
dc.subjectEpithelial Cells
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocytes, Smooth Muscle
dc.subjectMyoepithelioma
dc.subjectNeprilysin
dc.subjectSalivary Gland Neoplasms
dc.subjectTumor Markers, Biological
dc.titleCd10 (neutral Endopeptidase) Expression In Myoepithelial Cells Of Salivary Neoplasms.
dc.typeArtículos de revistas


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