Comparative Effects Of Pimecrolimus Cream Vehicle And Three Commercially Available Moisturizers On Skin Hydration And Transepidermal Water Loss.

dc.creatorVergnanini, André L
dc.creatorAoki, Valeria
dc.creatorTakaoka, Roberto
dc.creatorMadi, Julio
dc.date2010-May
dc.date2015-11-27T13:17:47Z
dc.date2015-11-27T13:17:47Z
dc.date.accessioned2018-03-29T01:10:45Z
dc.date.available2018-03-29T01:10:45Z
dc.identifierThe Journal Of Dermatological Treatment. v. 21, n. 3, p. 126-9, 2010-May.
dc.identifier1471-1753
dc.identifier10.3109/09546630903188403
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20394488
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198816
dc.identifier20394488
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299049
dc.descriptionHydration and integrity of the horny layer is essential to normal skin function. Comparison of the hydrating properties of three moisturizers with pimecrolimus cream vehicle. Four test preparations (high-quality skin cream, cold cream emulsion, emollient oil, pimecrolimus cream vehicle) were applied to four different regions of the forearms and legs. Transepidermal water loss (TEWL) was assessed by evaporimetry at baseline, and 3 and 6 hours after arm application, and electrical capacitance was assessed by corneometry at baseline, and 1, 2, 3 and 6 hours after leg application. Corneometry assessment - in terms of efficacy in moisturizing the skin, test preparations were ranked (best to worst): high-quality skin cream (45.9 arbitrary units versus 75.3; p < 0.001) > pimecrolimus vehicle cream (46.6 versus 61.5; p < 0.001) > emollient oil (43.5 versus 54.8; p = 0.006) > cold cream emulsion (44.8 versus 49.9; p = 0.738). Untreated skin (control) had a mean capacitance of 44.8 units at baseline and 48.5 units at endpoint. Evaporimetry (assessment of TEWL) revealed no significant differences between control and any test preparation at any timepoint. Pimecrolimus cream vehicle has skin hydration properties comparable with highly effective commercially available products. No test preparation had a significant effect on TEWL.
dc.description21
dc.description126-9
dc.languageeng
dc.relationThe Journal Of Dermatological Treatment
dc.relationJ Dermatolog Treat
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Cutaneous
dc.subjectAdult
dc.subjectAnalysis Of Variance
dc.subjectDermatologic Agents
dc.subjectDouble-blind Method
dc.subjectEmollients
dc.subjectFemale
dc.subjectHumans
dc.subjectIchthyosis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPharmaceutical Vehicles
dc.subjectProbability
dc.subjectSkin Absorption
dc.subjectSkin Care
dc.subjectTacrolimus
dc.subjectWater
dc.subjectYoung Adult
dc.titleComparative Effects Of Pimecrolimus Cream Vehicle And Three Commercially Available Moisturizers On Skin Hydration And Transepidermal Water Loss.
dc.typeArtículos de revistas


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