dc.creatorBotelho, Ana Paula
dc.creatorGameiro, Gustavo Hauber
dc.creatorTuma, Carlos Eduardo da Silva Nossa
dc.creatorMarcondes, Fernanda Klein
dc.creatorde Arruda Veiga, Maria Cecília Ferraz
dc.date2010-May
dc.date2015-11-27T13:17:47Z
dc.date2015-11-27T13:17:47Z
dc.date.accessioned2018-03-29T01:10:44Z
dc.date.available2018-03-29T01:10:44Z
dc.identifierStress (amsterdam, Netherlands). v. 13, n. 3, p. 269-75, 2010-May.
dc.identifier1607-8888
dc.identifier10.3109/10253890903362645
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20392197
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198813
dc.identifier20392197
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299046
dc.descriptionThe temporomandibular joint (TMJ) formalin test was used to evaluate the effects of acute restraint stress on the nociceptive behavioral responses of female rats during proestrus and estrus phases of the estrous cycle. Rats were subjected to one session of restraint stress (15, 30 min or 1 h). They were then either immediately killed to allow the collection of blood for hormonal radioimmunoassay determinations or subjected to TMJ formalin test to evaluate nociception. All stress protocols significantly raised the plasma concentrations of corticosterone. The performance of rats subjected to 15 and 30 min of restraint stress was similar to that of control rats, whereas rats that were stressed for 1 h showed a decrease in nociceptive responses, during both proestrus and estrus phases. The stress-induced analgesia (SIA) was greater in the proestrus phase. To evaluate the role of kappa-opioid receptors, the selective receptor kappa-opioid antagonist nor-binaltorphimine (nor-BNI; 200 microg or saline) was injected into the TMJ 24 h prior to the 1 h stress period and the TMJ formalin test. The local administration of nor-BNI partially reversed the SIA during the proestrus phase. These findings suggest that (1) acute stress for 1 h can produce analgesia both during proestrus and estrus phases; this effect is greater during the proestrus phase and (2) kappa-opioid receptor activation is involved in the SIA observed in the proestrus phase.
dc.description13
dc.description269-75
dc.languageeng
dc.relationStress (amsterdam, Netherlands)
dc.relationStress
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectEstrus
dc.subjectFemale
dc.subjectFormaldehyde
dc.subjectNaltrexone
dc.subjectNarcotic Antagonists
dc.subjectNociceptors
dc.subjectPain
dc.subjectPain Measurement
dc.subjectProestrus
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Opioid
dc.subjectRestraint, Physical
dc.subjectStress, Physiological
dc.subjectTemporomandibular Joint
dc.subjectTemporomandibular Joint Disorders
dc.titleThe Effects Of Acute Restraint Stress On Nociceptive Responses Evoked By The Injection Of Formalin Into The Temporomandibular Joint Of Female Rats.
dc.typeArtículos de revistas


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