Antiproliferative Effect Of Benzophenones And Their Influence On Cathepsin Activity.

dc.creatorMurata, Ramiro Mendonça
dc.creatorYatsuda, Regiane
dc.creatordos Santos, Marcelo Henrique
dc.creatorKohn, Luciana K
dc.creatorMartins, Felipe Terra
dc.creatorNagem, Tanus Jorge
dc.creatorAlencar, Severino Matias
dc.creatorde Carvalho, João Ernesto
dc.creatorRosalen, Pedro Luiz
dc.date2010-Mar
dc.date2015-11-27T13:17:36Z
dc.date2015-11-27T13:17:36Z
dc.date.accessioned2018-03-29T01:10:27Z
dc.date.available2018-03-29T01:10:27Z
dc.identifierPhytotherapy Research : Ptr. v. 24, n. 3, p. 379-83, 2010-Mar.
dc.identifier1099-1573
dc.identifier10.1002/ptr.2954
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19653314
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198737
dc.identifier19653314
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298970
dc.descriptionThe antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated garciniaphenone and the tetraprenylated benzophenone 7-epiclusianone, was investigated against human cancer cell lines. The antiproliferative activity on melanoma (UACC-62), breast (MCF-7), drug-resistant breast (NCI-ADR), lung/non-small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786-0), lung (NCI-460) and tongue (CRL-1624 and CRL-1623) cancer cells was determined using spectrophotometric quantification of the cellular protein content. The effect of these benzophenones on the activity of cathepsins B and G was also investigated. Garciniaphenone displayed cytostatic activity in all cell lines, whereas 7-epiclusianone showed a dose-dependent cytotoxic effect. The IC(50) values for cell proliferation revealed that 7-epiclusianone is more active than garciniaphenone against most of the cell lines. Furthermore, the antiproliferative effects demonstrated by garciniaphenone and 7-epiclusianone were related to their cathepsin inhibiting properties. In conclusion, 7-epiclusianone is a promising naturally occurring agent which displays multiple inhibitory effects which may be working in concert to inhibit cancer cell proliferation in vitro. The putative pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition.
dc.description24
dc.description379-83
dc.languageeng
dc.relationPhytotherapy Research : Ptr
dc.relationPhytother Res
dc.rightsfechado
dc.rights(c) 2009 John Wiley & Sons, Ltd.
dc.sourcePubMed
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectBenzophenones
dc.subjectBenzoquinones
dc.subjectCathepsins
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectClusiaceae
dc.subjectEnzyme Inhibitors
dc.subjectHumans
dc.subjectInhibitory Concentration 50
dc.subjectMolecular Structure
dc.subjectPlant Extracts
dc.titleAntiproliferative Effect Of Benzophenones And Their Influence On Cathepsin Activity.
dc.typeArtículos de revistas


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