Expression Profile And Distribution Of Efhc1 Gene Transcript During Rodent Brain Development.

dc.creatorConte, Fábio F
dc.creatorRibeiro, Patrícia A O
dc.creatorMarchesini, Rafael B
dc.creatorPascoal, Vinícius D B
dc.creatorSilva, Joelcimar M
dc.creatorOliveira, Amanda R
dc.creatorGilioli, Rovílson
dc.creatorSbragia, Lourenço
dc.creatorBittencourt, Jackson C
dc.creatorLopes-Cendes, Iscia
dc.date2009-Sep
dc.date2015-11-27T13:15:58Z
dc.date2015-11-27T13:15:58Z
dc.date.accessioned2018-03-29T01:10:10Z
dc.date.available2018-03-29T01:10:10Z
dc.identifierJournal Of Molecular Neuroscience : Mn. v. 39, n. 1-2, p. 69-77, 2009-Sep.
dc.identifier1559-1166
dc.identifier10.1007/s12031-009-9179-6
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19191033
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198666
dc.identifier19191033
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298899
dc.descriptionOne of the putative causative genes for juvenile myoclonic epilepsy (JME) is EFHC1. We report here the expression profile and distribution of Efhc1 messenger RNA (mRNA) during mouse and rat brain development. Real-time polymerase chain reaction revealed that there is no difference in the expression of Efhc1 mRNA between right and left hemispheres in both species. In addition, the highest levels of Efhc1 mRNA were found at intra-uterine stages in mouse and in adulthood in rat. In common, there was a progressive decrease in Efhc1 expression from 1-day-old neonates to 14-day-old animals in both species. In situ hybridization studies showed that rat and mouse Efhc1 mRNAs are expressed in ependymal cells of ventricle walls. Our findings suggest that Efhc1 expression is more important during initial phases of brain development and that at this stage it could be involved in key developmental mechanisms underlying JME.
dc.description39
dc.description69-77
dc.languageeng
dc.relationJournal Of Molecular Neuroscience : Mn
dc.relationJ. Mol. Neurosci.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBrain
dc.subjectCalcium-binding Proteins
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Developmental
dc.subjectIn Situ Hybridization
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMolecular Sequence Data
dc.subjectMyoclonic Epilepsy, Juvenile
dc.subjectRna, Messenger
dc.subjectRats
dc.titleExpression Profile And Distribution Of Efhc1 Gene Transcript During Rodent Brain Development.
dc.typeArtículos de revistas


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