Artículos de revistas
Analysis Of The Histologic Features In The Differential Diagnosis Of Intrahepatic Neonatal Cholestasis.
Registro en:
World Journal Of Gastroenterology : Wjg. v. 15, n. 4, p. 478-83, 2009-Jan.
2219-2840
19152454
Autor
Bellomo-Brandao, Maria Angela
Escanhoela, Cecilia A F
Meirelles, Luciana R
Porta, Gilda
Hessel, Gabriel
Institución
Resumen
To compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. Liver biopsies from 86 infants with IHNC were evaluated. The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life. The following histologic features were evaluated: cholestasis, eosinophilia, giant cells, erythropoiesis, siderosis, portal fibrosis, and the presence of a septum. Based on the diagnosis, patients were classified into three groups: group 1 (infectious; n=18), group 2 (genetic-endocrine-metabolic; n=18), and group 3 (idiopathic; n=50). There were no significant differences with respect to the following variables: cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and presence of a septum. A significant difference was observed with respect to erythropoiesis, which was more severe in group 1 (Fisher's exact test, P=0.016). A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum. 15 478-83