Figures Of Merit In The Quantification Of Ibuprofen Enantiomers By Chiral Hplc.

dc.creatorValderrama, Patrícia
dc.creatorRomero, Adriano Lopes
dc.creatorImamura, Paulo Mitsuo
dc.creatorPoppi, Ronei Jesus
dc.date2009-Oct
dc.date2015-11-27T13:15:36Z
dc.date2015-11-27T13:15:36Z
dc.date.accessioned2018-03-29T01:09:32Z
dc.date.available2018-03-29T01:09:32Z
dc.identifierJournal Of Chromatographic Science. v. 47, n. 9, p. 777-80, 2009-Oct.
dc.identifier1945-239X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19835687
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198500
dc.identifier19835687
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298733
dc.descriptionThe determination of ibuprofen (IBU) enantiomers by chiral high-performance liquid chromatographic is described. The methodology is based on chiral recognition of ibuprofen by a chiral column based on cellulose tris(4-methylbenzoate) coated on silica gel (Chiralcel OJ-H). The mobile phase is n-hexane-2-propanol-trifluoroacetic acid (98:2:0.1, v/v/v). The flow rate was 1.0 mL/min, and UV detection was 254 nm. The samples of ibuprofen were prepared in n-hexane in the concentration range 50-100% of (S)-IBU 1 x 10(-3) mol/L. Calibration and validation method were performed with six and nine samples, respectively. Goodness-of-fit measures represented by correlation coefficient, y-intercept, and slope of the regression line were 0.9836, 21373, 2162, respectively. Average of the relative error of the proposed method was 3.0%, 0.9% (S)-IBU selectivity, and 2162% (S)-IBU-1 sensitivity. The minimum concentration difference between two samples that could be determined in the linear dynamic range was 0.4% (S)-IBU. Limits of detection and quantification were 8.1 and 27.0% (S)-IBU, respectively. These results indicate that the proposed method can be employed for determination of the enantiomeric composition of IBU.
dc.description47
dc.description777-80
dc.languageeng
dc.relationJournal Of Chromatographic Science
dc.relationJ Chromatogr Sci
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectChromatography, High Pressure Liquid
dc.subjectIbuprofen
dc.subjectStereoisomerism
dc.titleFigures Of Merit In The Quantification Of Ibuprofen Enantiomers By Chiral Hplc.
dc.typeArtículos de revistas


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