Nanometer- And Submicrometer-sized Hollow Spheres Of Chondroitin Sulfate As A Potential Formulation Strategy For Anti-inflammatory Encapsulation.

dc.creatorReis, Adriano V
dc.creatorGuilherme, Marcos R
dc.creatorMattoso, Luiz H C
dc.creatorRubira, Adley F
dc.creatorTambourgi, Elias B
dc.creatorMuniz, Edvani C
dc.date2009-Feb
dc.date2015-11-27T13:15:31Z
dc.date2015-11-27T13:15:31Z
dc.date.accessioned2018-03-29T01:09:23Z
dc.date.available2018-03-29T01:09:23Z
dc.identifierPharmaceutical Research. v. 26, n. 2, p. 438-44, 2009-Feb.
dc.identifier0724-8741
dc.identifier10.1007/s11095-008-9732-y
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19005742
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198457
dc.identifier19005742
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298690
dc.descriptionThe synthesis of nanometer and submicrometer hollow particles could be a motivating way to imprint new therapeutic properties into a chondroitin sulfate-based hydrogel formulation. The use of hollowed polymer structures as a formulation strategy is expected to have an impact in the effective therapy in the treatment of rheumatoid arthritis. Chemical modification of the chondroitin sulfate with glycidyl methacrylate (GMA) was performed in water under thermal and acid stimuli. The hydrogel spheres were formed upon cross-linking reaction of modified chondroitin sulfate (CSM) in a water-in-benzyl alcohol nano-droplet emulsion. 1H NMR and 13C NMR spectra showed that the carbon-carbon pi-bonds coming from the GMA were incorporated onto backbones of CS. 13C-CP/MAS NMR spectra revealed that the formation of the CSM hydrogel spheres during the dispersion stage occurred by way of carbon-carbon pi-bonds on the CSM structure. The spherical shapes of the particles with diameters in the range of 20 microm to 500 nm were very clearly verified by SEM images where the dark center and edge of the hollow spheres could be identified easily. Nanometer- and submicrometer-sized hydrogel spheres with hollow interior were produced from chondroitin sulfate by using a new strategy of hydrogel synthesis.
dc.description26
dc.description438-44
dc.languageeng
dc.relationPharmaceutical Research
dc.relationPharm. Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAntirheumatic Agents
dc.subjectBenzyl Alcohol
dc.subjectChemistry, Pharmaceutical
dc.subjectChondroitin Sulfates
dc.subjectCross-linking Reagents
dc.subjectDrug Carriers
dc.subjectDrug Compounding
dc.subjectEmulsions
dc.subjectEpoxy Compounds
dc.subjectHydrogels
dc.subjectHydrogen-ion Concentration
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMethacrylates
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMicrospheres
dc.subjectModels, Chemical
dc.subjectNanospheres
dc.subjectParticle Size
dc.subjectPorosity
dc.subjectSurface Properties
dc.subjectTemperature
dc.subjectWater
dc.titleNanometer- And Submicrometer-sized Hollow Spheres Of Chondroitin Sulfate As A Potential Formulation Strategy For Anti-inflammatory Encapsulation.
dc.typeArtículos de revistas


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