Long-term Therapy With Deflazacort Decreases Myocardial Fibrosis In Mdx Mice.

dc.creatorMarques, Maria Julia
dc.creatorOggiam, Daniella Silva
dc.creatorBarbin, Isabel Cristina Chagas
dc.creatorFerretti, Renato
dc.creatorSanto Neto, Humberto
dc.date2009-Sep
dc.date2015-11-27T13:15:25Z
dc.date2015-11-27T13:15:25Z
dc.date.accessioned2018-03-29T01:09:11Z
dc.date.available2018-03-29T01:09:11Z
dc.identifierMuscle & Nerve. v. 40, n. 3, p. 466-8, 2009-Sep.
dc.identifier0148-639X
dc.identifier10.1002/mus.21341
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19623634
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198411
dc.identifier19623634
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298644
dc.descriptionWe evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.
dc.description40
dc.description466-8
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents
dc.subjectFibrosis
dc.subjectHeart
dc.subjectMice
dc.subjectMice, Inbred Mdx
dc.subjectMuscular Dystrophy, Animal
dc.subjectMyocardium
dc.subjectPregnenediones
dc.subjectTime Factors
dc.titleLong-term Therapy With Deflazacort Decreases Myocardial Fibrosis In Mdx Mice.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución