Nad(p)h- And Superoxide-dependent Nitric Oxide Degradation By Rat Liver Mitochondria.

dc.creatorOliveira, Halley Caixeta
dc.creatorSaviani, Elzira Elisabeth
dc.creatorSalgado, Ione
dc.date2009-Jul
dc.date2015-11-27T13:15:19Z
dc.date2015-11-27T13:15:19Z
dc.date.accessioned2018-03-29T01:09:00Z
dc.date.available2018-03-29T01:09:00Z
dc.identifierFebs Letters. v. 583, n. 13, p. 2276-80, 2009-Jul.
dc.identifier1873-3468
dc.identifier10.1016/j.febslet.2009.06.012
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19524570
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198364
dc.identifier19524570
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298597
dc.descriptionMitochondria consume nitric oxide (NO) mainly through reaction with superoxide anion (O(2)(-)). Here, we analyzed the O(2)(-) sources for NO degradation by isolated rat liver mitochondria. Electron leakage from complex III and reverse electron transport to complex I accounted for O(2)(-)-dependent NO degradation by mitochondria in the presence of a protonmotive force. Mitochondria incubated with NAD(P)H also presented intense O(2)(-) generation and NO degradation rates that were insensitive to respiratory inhibitors and abolished after proteinase treatment. These results suggest that an outer membrane-localized NAD(P)H oxidase activity, in addition to the electron leakage from the respiratory chain, promotes O(2)(-)-dependent NO degradation in rat liver mitochondria.
dc.description583
dc.description2276-80
dc.languageeng
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectMale
dc.subjectMitochondria, Liver
dc.subjectNad
dc.subjectNadph Oxidase
dc.subjectNitric Oxide
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuperoxides
dc.titleNad(p)h- And Superoxide-dependent Nitric Oxide Degradation By Rat Liver Mitochondria.
dc.typeArtículos de revistas


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