The Influence Of Lidocaine And Racemic Bupivacaine On Neuromuscular Blockade Produced By Rocuronium. A Study In Rat Phrenic Nerve-diaphragm Preparation.

dc.creatorCarvalho, Vanessa Henriques
dc.creatorBraga, Angélica de Fátima de Assunção
dc.creatorBraga, Franklin Sarmento da Silva
dc.creatorLoyola, Yolanda Christina S
dc.creatorde Araújo, Daniele Ribeiro
dc.creatorMantovani, Mario
dc.date
dc.date2015-11-27T13:15:18Z
dc.date2015-11-27T13:15:18Z
dc.date.accessioned2018-03-29T01:08:59Z
dc.date.available2018-03-29T01:08:59Z
dc.identifierActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 24, n. 3, p. 211-5
dc.identifier1678-2674
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19504004
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198356
dc.identifier19504004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298589
dc.descriptionTo evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium. Rats were distributed in 5 groups (n = 5) in agreement with the studied drugs: lidocaine, racemic bupivacaine, rocuronium, separately (Groups I, II, III); rocuronium in preparations exposed to local anesthetics (Groups IV, V). The concentrations used were: 20 microg/mL, 5 microg/mL and 4 microg/mL, for lidocaine, bupivacaine and rocuronium, respectively. It was evaluated: 1) amplitude of diaphragm muscle response to indirect stimulation, before and 60 minutes after separately addition of lidocaine, racemic bupivacaine and rocuronium and the association of local anesthetics - rocuronium; 2) membrane potentials (MP) and miniature end-plate potentials (MEPP). Lidocaine and bupivacaine separately didn't alter the amplitude of muscle response and MP. In preparations previously exposed to lidocaine and racemic bupivacaine, the rocuronium blockade was significantly larger (90.10 +/- 9.15% and 100%, respectively), in relation to the produced by rocuronium separately (73.12 +/- 9.89%). Lidocaine caused an increase in the frequency of MEPP, being followed by blockade; racemic bupivacaine produced decrease being followed by blockade. Local anesthetics potentiated the blockade caused by rocuronium. The alterations of MEPP identify presynaptic action.
dc.description24
dc.description211-5
dc.languageeng
dc.relationActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia
dc.relationActa Cir Bras
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAndrostanols
dc.subjectAnesthetics, Local
dc.subjectAnimals
dc.subjectBupivacaine
dc.subjectDiaphragm
dc.subjectDrug Evaluation, Preclinical
dc.subjectElectric Stimulation
dc.subjectLidocaine
dc.subjectMale
dc.subjectMotor Endplate
dc.subjectNeuromuscular Blockade
dc.subjectNeuromuscular Junction
dc.subjectNeuromuscular Nondepolarizing Agents
dc.subjectPhrenic Nerve
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStatistics, Nonparametric
dc.titleThe Influence Of Lidocaine And Racemic Bupivacaine On Neuromuscular Blockade Produced By Rocuronium. A Study In Rat Phrenic Nerve-diaphragm Preparation.
dc.typeArtículos de revistas


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