Identification Of A Bioactive Compound Isolated From Brazilian Propolis Type 6.

dc.creatorCastro, Myrella Lessio
dc.creatordo Nascimento, Andréa Mendes
dc.creatorIkegaki, Masaharu
dc.creatorCosta-Neto, Cláudio M
dc.creatorAlencar, Severino M
dc.creatorRosalen, Pedro L
dc.date2009-Jul
dc.date2015-11-27T13:15:18Z
dc.date2015-11-27T13:15:18Z
dc.date.accessioned2018-03-29T01:08:57Z
dc.date.available2018-03-29T01:08:57Z
dc.identifierBioorganic & Medicinal Chemistry. v. 17, n. 14, p. 5332-5, 2009-Jul.
dc.identifier1464-3391
dc.identifier10.1016/j.bmc.2009.04.066
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19497755
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198350
dc.identifier19497755
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298583
dc.descriptionA prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
dc.description17
dc.description5332-5
dc.languageeng
dc.relationBioorganic & Medicinal Chemistry
dc.relationBioorg. Med. Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectActinomyces
dc.subjectAnimals
dc.subjectAnti-bacterial Agents
dc.subjectAntibiotics, Antineoplastic
dc.subjectBacterial Adhesion
dc.subjectBees
dc.subjectBenzophenones
dc.subjectBrazil
dc.subjectCell Survival
dc.subjectHela Cells
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectMicrobial Viability
dc.subjectMolecular Structure
dc.subjectMutation
dc.subjectPrenylation
dc.subjectPropolis
dc.subjectStaphylococcus
dc.titleIdentification Of A Bioactive Compound Isolated From Brazilian Propolis Type 6.
dc.typeArtículos de revistas


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