Comparison Of Blood Neoangiogenesis And Lymphatic Vascularization In Colorectal Adenomas From Patients With And Without Concomitant Colorectal Cancer.

dc.creatorMoreira, L R
dc.creatorSchenka, A A
dc.creatorFilho, P Latuf
dc.creatorLima, C S P
dc.creatorTrevisan, M A S
dc.creatorVassallo, J
dc.date2009-Jul
dc.date2015-11-27T13:15:14Z
dc.date2015-11-27T13:15:14Z
dc.date.accessioned2018-03-29T01:08:52Z
dc.date.available2018-03-29T01:08:52Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 42, n. 7, p. 593-8, 2009-Jul.
dc.identifier1414-431X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19466284
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198327
dc.identifier19466284
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298560
dc.descriptionBlood and lymphatic vessel proliferation is essential for tumor growth and progression. Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations. About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without concomitant cancer are missing. The aim of the present study is to compare the angiogenic and lymphatic patterns of adenomatous polyps from patients with and without sporadic cancer. Thirty adenomatous polyps (15 from patients with another principal malignant lesion, and 15 from patients without cancer) were submitted to immunohistochemical staining for CD105 (marker for neoangiogenesis) and D2-40 (marker for lymphatic endothelium). Microvessel density and total vascular area were determined by computer image analysis to quantify the immunostained and total areas, and to assess the number of microvessels. Adenomas from patients with carcinoma showed significantly higher values of total vascular area determined by immunostaining for CD105 (cutoff value = 4386 microm(2); P = 0.019) and of lymphatic microvessel density determined by immunostaining with D2-40 (cutoff value = 11.5; P = 0.041) when compared with those from patients without cancer. The present data indicate a significant increase in blood microvascular area and in lymphatic microvascular counts in adenomas removed from patients with cancer.
dc.description42
dc.description593-8
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdenomatous Polyps
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectAntibodies, Monoclonal
dc.subjectAntibodies, Monoclonal, Murine-derived
dc.subjectAntigens, Cd
dc.subjectBiological Markers
dc.subjectColorectal Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectLymphangiogenesis
dc.subjectLymphatic Vessels
dc.subjectMale
dc.subjectMicrocirculation
dc.subjectMiddle Aged
dc.subjectNeovascularization, Pathologic
dc.subjectReceptors, Cell Surface
dc.subjectRetrospective Studies
dc.titleComparison Of Blood Neoangiogenesis And Lymphatic Vascularization In Colorectal Adenomas From Patients With And Without Concomitant Colorectal Cancer.
dc.typeArtículos de revistas


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