A New Paradigm In The Periodontal Disease Progression: Gingival Connective Tissue Remodeling With Simultaneous Collagen Degradation And Fibers Thickening.

dc.creatorLorencini, M
dc.creatorSilva, J A F
dc.creatorAlmeida, C A
dc.creatorBruni-Cardoso, A
dc.creatorCarvalho, H F
dc.creatorStach-Machado, D R
dc.date2009-Feb
dc.date2015-11-27T13:15:08Z
dc.date2015-11-27T13:15:08Z
dc.date.accessioned2018-03-29T01:08:41Z
dc.date.available2018-03-29T01:08:41Z
dc.identifierTissue & Cell. v. 41, n. 1, p. 43-50, 2009-Feb.
dc.identifier0040-8166
dc.identifier10.1016/j.tice.2008.07.001
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18801546
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198281
dc.identifier18801546
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298514
dc.descriptionBacterial dental plaque is considered to be the main cause of periodontal diseases, but progression of the disease is also related to the host inflammatory response. The earliest affected tissue is the gingiva, but the specific mechanisms involved in the onset of this condition remain unclear. Frequently, collagen degradation is pointed as the main marker of periodontal disease progression, but the organization of the fibers in the gingival tissue is still unknown. The aim of the present study was to investigate the gingival extracellular matrix in a model of ligature-induced periodontal disease. Analysis of the microbiota indicated a progressive increase in the ratio of Gram-negative/Gram-positive microorganisms. There was no difference in the organization of reticulin fibers next to the epithelial basement membrane, whereas the arrangement of collagen fibers in the gingival connective tissue was significantly affected. Animals with inflammation presented a reduction of 35% in the total area occupied by collagen fibers. However, these fibers were thicker and more densely packed. These alterations involve type I, type III and type VI collagens as determined by immunohistochemistry. The results demonstrated the occurrence of marked reorganization of the gingival extracellular matrix in response to the inflammatory process, indicating a new paradigm in the periodontal disease progression: collagen degradation and fibers thickening, simultaneously.
dc.description41
dc.description43-50
dc.languageeng
dc.relationTissue & Cell
dc.relationTissue Cell
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCollagen
dc.subjectCollagen Type I
dc.subjectCollagen Type Iii
dc.subjectCollagen Type Vi
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectExtracellular Matrix
dc.subjectGingiva
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectPeriodontal Diseases
dc.subjectRats
dc.subjectRats, Wistar
dc.titleA New Paradigm In The Periodontal Disease Progression: Gingival Connective Tissue Remodeling With Simultaneous Collagen Degradation And Fibers Thickening.
dc.typeArtículos de revistas


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