Sarcoplasmic-endoplasmic-reticulum Ca2+-atpase And Calsequestrin Are Overexpressed In Spared Intrinsic Laryngeal Muscles Of Dystrophin-deficient Mdx Mice.

dc.creatorFerretti, Renato
dc.creatorMarques, Maria Julia
dc.creatorPertille, Adriana
dc.creatorSanto Neto, Humberto
dc.date2009-May
dc.date2015-11-27T13:15:00Z
dc.date2015-11-27T13:15:00Z
dc.date.accessioned2018-03-29T01:08:30Z
dc.date.available2018-03-29T01:08:30Z
dc.identifierMuscle & Nerve. v. 39, n. 5, p. 609-15, 2009-May.
dc.identifier0148-639X
dc.identifier10.1002/mus.21154
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19301368
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198231
dc.identifier19301368
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298464
dc.descriptionIn the mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILM) are protected and do not undergo myonecrosis. We investigated whether this protection is related to an increased expression of calcium-binding proteins, which may protect against the elevated calcium levels seen in dystrophic fibers. The expression of sarcoplasmic-endoplasmic-reticulum Ca(2+)-ATPase and calsequestrin was examined in ILM and in nonspared limb muscles of control and mdx mice using immunofluorescence and immunoblotting. Dystrophic ILM presented a significant increase in the proteins studied when compared to controls. The increase of Ca(2+)-handling proteins in dystrophic ILM may permit better maintenance of calcium homeostasis, with the consequent absence of myonecrosis. The results further support the concept that abnormal Ca(2+)-handling is involved in dystrophinopathies. Muscle Nerve, 2009.
dc.description39
dc.description609-15
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCalsequestrin
dc.subjectDystrophin
dc.subjectGene Expression Regulation
dc.subjectLaryngeal Muscles
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectSarcoplasmic Reticulum Calcium-transporting Atpases
dc.titleSarcoplasmic-endoplasmic-reticulum Ca2+-atpase And Calsequestrin Are Overexpressed In Spared Intrinsic Laryngeal Muscles Of Dystrophin-deficient Mdx Mice.
dc.typeArtículos de revistas


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