Comparative Cytokeratin Expression In The Different Cell Types Of Salivary Gland Mucoepidermoid Carcinoma.

dc.creatorAzevedo, Rebeca Souza
dc.creatorde Almeida, Oslei Paes
dc.creatorKowalski, Luiz Paulo
dc.creatorPires, Fábio Ramôa
dc.date2008-Dec
dc.date2015-11-27T13:13:29Z
dc.date2015-11-27T13:13:29Z
dc.date.accessioned2018-03-29T01:08:02Z
dc.date.available2018-03-29T01:08:02Z
dc.identifierHead And Neck Pathology. v. 2, n. 4, p. 257-64, 2008-Dec.
dc.identifier1936-0568
dc.identifier10.1007/s12105-008-0074-1
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20614291
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198117
dc.identifier20614291
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298350
dc.descriptionMucoepidermoid carcinoma is the most common malignant salivary gland tumor, composed of several different cell types, with controversial histogenesis. The aim of this study was to assess the expression of cytokeratins in mucoepidermoid carcinoma, comparing to cytokeratin expression in normal salivary glands, in order to establish a possible correlation between tumor cells immunostaining and mucoepidermoid carcinoma histogenesis and differentiation. Eighty cases of salivary gland mucoepidermoid carcinoma were immunohistochemically examined with the use of antibodies against cytokeratins 6, 7, 8, 13, 14, 18, and 19. Cytokeratin expression varied according to the cellular type: squamous cells presented high expression of cytokeratins 6, 7, 8, 14, 18, and 19; intermediate and mucous cells of cytokeratin 7; clear and columnar cells of cytokeratins 6, 7, 8 and the latter also expressed cytokeratin 18. Cytokeratin 13 expression was low in all cell types. Cytokeratin immunoexpression in mucoepidermoid carcinoma was variable according to the cellular type; but regardless of the cellular type studied, cytokeratins 7 and 13 were, respectively, constantly high and low expressed. The immunoprofile of the normal salivary glands was variable according to the component but, in general, cytokeratin profile in mucoepidermoid carcinoma showed similarity to the immunoexpression on the excretory duct unit of normal salivary glands.
dc.description2
dc.description257-64
dc.languageeng
dc.relationHead And Neck Pathology
dc.relationHead Neck Pathol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectCarcinoma, Mucoepidermoid
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKeratins
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSalivary Gland Neoplasms
dc.subjectSalivary Glands, Minor
dc.subjectTumor Markers, Biological
dc.subjectYoung Adult
dc.subjectClear Cell
dc.subjectColumnar Cell
dc.subjectCytokeratin
dc.subjectDifferentiation
dc.subjectHistogenesis
dc.subjectImmunohistochemistry
dc.subjectIntermediate Cell
dc.subjectMucoepidermoid Carcinoma
dc.subjectMucous Cell
dc.subjectOncocyitic Cell
dc.subjectSalivary Glands
dc.subjectSquamous Cell
dc.titleComparative Cytokeratin Expression In The Different Cell Types Of Salivary Gland Mucoepidermoid Carcinoma.
dc.typeArtículos de revistas


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